Cathie Wood’s ARK ETF adjusts portfolio with major trades in Exact Sciences, Guardant Health

Cathie Wood’s ARK ETF published their daily trades for Monday, October 20th 2025, revealing a series of significant buys and sells across various sectors. The most substantial trade of the day was the sale of shares in Guardant Health Inc (NASDAQ:GH), with ARK’s ARKG ETF offloading 124,233 shares valued at approximately $8.13 million. This move comes amid a broader trend of ARK reducing its holdings in the precision oncology company.

On the acquisition front, ARK’s ARKG ETF made a notable investment in Exact Sciences Corp (NASDAQ:EXAS), purchasing 90,731 shares worth around $5.56 million. This buy signals a growing interest from ARK in the diagnostics company, known for its non-invasive cancer screening tests.

Another significant transaction was the sale of shares in Kratos Defense and Security Solutions Inc (NASDAQ:KTOS) through the ARKQ ETF. A total of 96,699 shares were sold, amounting to roughly $8.04 million. The defense contractor has been a recurring subject in ARK’s recent sell-offs, indicating a potential shift in strategy or reallocation of resources within the ETF.

In the technology sector, ARK’s ARKQ ETF bought 9,174 shares of Intuitive Surgical Inc (NASDAQ:ISRG), a leader in robotic-assisted surgery, with a total value of approximately $4.09 million. This purchase adds to ARK’s existing stake in the company, reflecting a sustained confidence in its growth prospects.

The ARKQ ETF also invested in L3Harris Technologies Inc (NYSE:LHX), acquiring 11,714 shares valued at around $3.33 million. L3Harris, a technology and defense company, has been receiving increased attention from ARK, as evidenced by additional purchases made last week.

Other trades included further investment in companies like BYD Co Ltd (OTC:BYDDY), Illumina Inc (NASDAQ:ILMN), and Qualcomm Inc (NASDAQ:QCOM), with ARK buying shares worth $941,160, $2.77 million, and $3.33 million, respectively. These investments underscore ARK’s focus on companies with innovative technologies and potential for significant impact in their respective industries.

Smaller, yet strategic, buys were made in Klarna Group PLC (Private:KLAR), Synopsys Inc (NASDAQ:SNPS), and Teledyne Technologies Inc (NYSE:TDY), with ARK spending $2.49 million, $1.65 million, and $2.51 million on these stocks, respectively.

On the sell side, ARK continued to divest from Oklo Inc (Private:OKLO), Palantir Technologies Inc (NYSE:PLTR), Quantum-Si Inc (NASDAQ:QSI), Roblox Corp (Pre-Reincorporation) (NYSE:RBLX), Shopify Inc (NYSE:SHOP), and SoFi Technologies Inc (NASDAQ:SOFI), with sales amounting to $8.72 million, $3.60 million, $198,015, $3.64 million, $3.53 million, and $3.70 million, respectively. These disposals reflect ARK’s dynamic portfolio management and ongoing reassessment of its investment theses.

Investors following Cathie Wood’s ARK ETFs can anticipate further adjustments as the funds continue to navigate the evolving market landscape, capitalizing on emerging opportunities and divesting from less favorable positions.

This article was generated with the support of AI and reviewed by an editor. For more information see our T&C.