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SOUTH SAN FRANCISCO - CERo Therapeutics Holdings, Inc. (NASDAQ:CERO), a company specializing in engineered T cell immunotherapies with a current market capitalization of $1.6 million, has announced the allowance of two key patent applications by the U.S. Patent and Trademark Office (USPTO), marking a significant expansion of its intellectual property rights. According to InvestingPro data, while the company maintains more cash than debt on its balance sheet, it faces ongoing profitability challenges with negative earnings per share of -$27.84. The patents are central to the company's lead compound, CER-1236, which is designed to treat cancer by combining a phosphatidylserine-targeting CD4+ CER-T cell with either a CD8+ CAR-T cell or a CD8+ recombinant TCR-T cell.
The first patent application, No. 17/040,472, allowed on March 13, 2025, covers the composition and methods of using CER-1236. The second, No. 17/040,317, allowed on March 24, 2025, includes design aspects of the chimeric TIM4 receptors that are part of CER-1236. This latter patent provides protection for a chimeric TIM4 receptor that combines a TIM4 binding domain with canonical T cell signaling domains.
With these allowances, CERo's intellectual property now encompasses nine patent families and extends protection in the United States until 2039. The company's portfolio globally includes 17 issued patents and allowed patent applications. Despite recent intellectual property achievements, InvestingPro analysis shows the stock has experienced significant volatility, with a notable 19.6% gain in the past week, though trading well below its 52-week high of $210.
CEO Chris Ehrlich expressed the company's confidence in the novelty and therapeutic potential of their technology, emphasizing the importance of these patents for CERo's market success. The recent patent allowances follow the announcements of CERo's initial trial site for its Phase 1 trial in Acute Myeloid Leukemia (AML) and the cleared Investigational New Drug (IND) application to begin human trials for ovarian and non-small cell lung cancers.
CERo's proprietary approach aims to merge characteristics of innate and adaptive immunity into a single therapeutic construct, which the company believes could offer broader therapeutic applications than existing CAR-T cell therapies. The company is preparing to initiate clinical trials for CER-1236 in 2025, targeting hematological malignancies.
This news is based on a press release statement and reflects the company's ongoing efforts to strengthen its position in the field of cancer immunotherapy. As the company moves forward with its clinical trials, the expanded patent protection is expected to play a crucial role in securing its proprietary technology and therapeutic approaches. InvestingPro subscribers have access to over 10 additional key insights about CERO's financial health and market position, essential for understanding the company's investment potential ahead of its next earnings report on April 9, 2025.
In other recent news, CERo Therapeutics Holdings, Inc. has announced the allowance of two significant patent applications by the U.S. Patent and Trademark Office, which strengthens its intellectual property position for its lead compound, CER-1236, a potential cancer treatment. The company has also received FDA approval to proceed with a Phase 1 clinical trial for CER-1236, targeting advanced solid tumors such as non-small cell lung cancer and ovarian cancer. This trial follows the initiation of another trial for acute myeloid leukemia (AML). Additionally, CERo has partnered with UC Davis for the production of CER-1236, a crucial step before commencing patient dosing, which is expected in the first half of 2025.
The FDA's positive review of an amendment to CERo's Investigational New Drug application marks the completion of the company's final obligation before patient dosing. This development is expected to shorten the manufacturing timeline by approximately one week. CERo's proprietary platform aims to merge characteristics of both innate and adaptive immunity into its Chimeric Engulfment Receptor T cells (CER-T). Recent preclinical studies have shown promising results for CER-1236 in treating ovarian cancer without generating toxicity in animal models. These developments reflect CERo's broader efforts to advance its immunotherapy platform and strengthen its market position in cancer treatment.
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