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Ionis Pharmaceuticals (NASDAQ:IONS) Chief Executive Officer Brett P. Monia sold 437 shares of the company’s common stock on October 6, 2025, according to a recent SEC filing. The shares were sold at a price of $69.2637, for a total transaction value of $30,268. The sale comes as the stock trades near its 52-week high of $71.87, having delivered an impressive 174% return over the past six months. According to InvestingPro analysis, the stock’s technical indicators suggest it’s currently in overbought territory.
The sale was executed under a pre-arranged Rule 10b5-1 trading plan adopted by Monia on August 13, 2024. Following the transaction, Monia directly owns 179,572 shares of Ionis Pharmaceuticals, which currently has a market capitalization of $11.17 billion. InvestingPro offers 12 additional investment tips and a comprehensive Pro Research Report for IONS, providing deeper insights into the company’s valuation and financial health.
In other recent news, Ionis Pharmaceuticals has been the focus of several analyst updates and strategic announcements. The company recently held its Innovation Day, where it showcased its long-term revenue guidance and highlighted positive Phase 3 trial results for olezarsen and zilganersen. Stifel maintained a Hold rating on Ionis but raised its price target to $67, citing developments in the TTR market. Oppenheimer increased its price target to $90, maintaining an Outperform rating, following pipeline progress and recent trial successes. JPMorgan upgraded Ionis from Neutral to Overweight, significantly raising its price target to $80, acknowledging the positive outcomes for olezarsen in severe hypertriglyceridemia and other pipeline updates. Additionally, Ionis outlined a growth strategy aiming for four product launches by 2026, with two already achieved in less than nine months. The company also anticipates four partner-led launches by the end of 2027. These developments reflect Ionis’s ongoing efforts to expand its product offerings and strengthen its market position.
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