H.C. Wainwright maintains $47 target on Stoke Therapeutics stock

Published 20/03/2025, 12:32
H.C. Wainwright maintains $47 target on Stoke Therapeutics stock

On Thursday, H.C. Wainwright research firm reiterated its Buy rating and $47.00 price target for Stoke Therapeutics (NASDAQ:STOK), a biotechnology company focused on treatments for genetic diseases. Currently trading at $8.26, the stock appears undervalued according to InvestingPro analysis, with analyst targets ranging from $15 to $47. The reaffirmation comes in light of recent company announcements and leadership changes.

Stoke Therapeutics disclosed on March 18, 2025, that its pivotal EMPEROR study is scheduled to begin in the second quarter of 2025, with the first patient expected to receive a dose in the third quarter of the same year. This update coincides with the news that Dr. Edward Kaye is stepping down from his role as CEO, paving the way for a successor with potential commercial expertise. InvestingPro data shows the company maintains a strong liquidity position with a current ratio of 5.81, though it’s currently burning through cash rapidly.

Analysts at H.C. Wainwright expressed confidence in the timing of the leadership transition, citing the company’s solid foundation following a successful Phase 1/2 trial for its leading drug candidate, zorevunersen. The drug, which targets a disease currently lacking approved disease-modifying treatments, has demonstrated clear safety and efficacy data.

The open-label extension (OLE) data from the trials underscored the potential of zorevunersen, showing a 70 mg loading dose followed by a 45 mg maintenance dose could achieve a median reduction in seizure frequency of 80-87% over eight months when combined with background therapy. This result, if replicated, could lead to final approval of the drug. Additionally, improvements in behavior and cognition were observed across various endpoints, suggesting zorevunersen could differentiate itself in the market and possibly extend its label, depending on Phase 3 outcomes.

Significantly, the Phase 1/2 and OLE data have aligned global regulatory agencies, streamlining the pathway for the Phase 3 trial and future commercialization efforts. Analysts also noted that Stoke’s recent deal with Biogen (NASDAQ:BIIB) arrived at a strategic time, potentially laying the groundwork for Stoke to become a commercial-stage entity. The quality of the forthcoming Phase 3 data and the initial launch may even position Stoke as a candidate for mergers and acquisitions.

In summary, H.C. Wainwright’s analysts stand by their Buy rating and price target for Stoke Therapeutics, highlighting the company’s progress and strategic positioning as it advances toward potential commercialization and further corporate development. With a market capitalization of $447 million and minimal debt-to-equity ratio of 0.01, the company shows promising financial fundamentals despite current unprofitability. Discover more insights and 6 additional ProTips for STOK with an InvestingPro subscription.

In other recent news, Stoke Therapeutics reported robust financial results for the fourth quarter, surpassing analysts’ expectations. The company announced adjusted earnings per share of -$0.18, which exceeded the projected -$0.55. Revenue also significantly outperformed estimates, reaching $22.61 million compared to the anticipated $4.1 million and up from $2.8 million in the same quarter last year. Despite these strong earnings, the announcement that CEO Edward M. Kaye will step down captured significant attention. Dr. Kaye, who has been at the helm for seven years, will transition to an advisory role while remaining on the board of directors. For the full year 2024, Stoke reported a net loss of $89 million, improving from a loss of $104.7 million in 2023, with annual revenue climbing to $36.6 million from $8.8 million year over year. The company ended 2024 with $246.7 million in cash and equivalents, bolstered by a $165 million payment from a collaboration with Biogen. Stoke anticipates this financial position will support its operations through mid-2028.

This article was generated with the support of AI and reviewed by an editor. For more information see our T&C.

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