Leerink raises Tourmaline Bio target to $54, affirms Outperform

Published 21/05/2025, 14:10
Leerink raises Tourmaline Bio target to $54, affirms Outperform

On Wednesday, Tourmaline Bio (NASDAQ:TRML), a biotechnology company with a market capitalization of $416 million, saw its price target increased by Leerink Partners from $49.00 to $54.00, while the firm sustained its Outperform rating on the stock. According to InvestingPro data, analysts maintain a strong buy consensus with price targets ranging from $35 to $70. The adjustment follows recent developments in the company’s clinical trials.

Leerink Partners highlighted the Phase 2 TRANQUILITY study for pacibekitug, an anti-IL-6 treatment for patients with atherosclerotic cardiovascular disease (ASCVD). Despite experiencing intraday volatility with shares dropping as much as 19% and closing down 3% against a 2% rise in the XBI, the results from the study are seen as promising. The analysts noted pacibekitug’s competitive efficacy and safety profile, emphasizing its less frequent dosing schedule as a key differentiator from competitors. InvestingPro analysis shows the company maintains a strong financial health score, with a current ratio of 33.87 and more cash than debt on its balance sheet.

The TRANQUILITY study’s outcomes have positioned Tourmaline Bio favorably, with Leerink Partners viewing the biotechnology firm as having a "differentiated, Phase 3-ready asset." This positions the company to potentially capitalize on the multi-billion dollar opportunity within the cardiovascular disease market.

Leerink’s analysis suggests that Tourmaline Bio’s strategic positioning could significantly enhance the company’s fundamental value. The less frequent dosing requirement of pacibekitug (every 12 weeks, compared to every 4 weeks for competing treatments) is expected to provide a competitive edge in the market.

The firm’s confidence in Tourmaline Bio is reflected in the raised price target, indicating a positive outlook for the stock’s performance. The endorsement of the Outperform rating suggests that Leerink Partners anticipates the stock to outperform the average total return of the stocks in the analyst’s coverage universe over the next 12 to 18 months. Based on InvestingPro’s Fair Value analysis, the stock appears slightly overvalued at current levels. Subscribers can access 8 additional ProTips and comprehensive financial metrics to make more informed investment decisions.

In other recent news, Tourmaline Bio revealed promising results from its Phase 2 TRANQUILITY trial of pacibekitug, demonstrating significant reductions in high-sensitivity C-reactive protein (hs-CRP), a marker associated with cardiovascular risk. The trial indicated that pacibekitug, an IL-6 inhibitor, achieved rapid and durable reductions in hs-CRP with quarterly dosing, showcasing a favorable safety profile. Despite these positive outcomes, the market reacted negatively, possibly due to concerns about the drug’s commercial viability. Analysts from Truist Securities maintained a Buy rating with a $63 price target, emphasizing the drug’s potential and Tourmaline’s solid financial position. Meanwhile, BMO Capital Markets reiterated an Outperform rating with a $35 price target, suggesting the market’s reaction was excessive and highlighting pacibekitug’s distinct profile. Tourmaline Bio plans to advance pacibekitug into Phase 3 trials for atherosclerotic cardiovascular disease and a Phase 2 trial for abdominal aortic aneurysm. The company also plans to share additional data at an upcoming medical conference. These developments indicate ongoing interest and potential strategic opportunities for Tourmaline Bio as it continues its clinical research.

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