Metagenomi stock target cut to $7 at H.C. Wainwright

Published 03/04/2025, 12:36
Metagenomi stock target cut to $7 at H.C. Wainwright

On Thursday, H.C. Wainwright adjusted its outlook on Metagenomi Inc (NASDAQ:MGX), reducing the 12-month price target to $7 from the previous $14, while still maintaining a Buy rating on the shares. Currently trading at $1.33, the stock sits near its 52-week low of $1.29, with analyst targets ranging from $13 to $21. According to InvestingPro data, the stock’s technical indicators suggest oversold conditions. The revision reflects the firm’s response to heightened regulatory uncertainties in the genetic medicines sector, following recent changes at the U.S. Food and Drug Administration (FDA).

The departure of Dr. Peter Marks, who led the FDA’s Center for Biologics Evaluation and Research, is seen as a significant event, potentially increasing the hurdles for approving genetic medicines. Analysts at H.C. Wainwright considered Dr. Marks an important supporter of the genetic medicines industry, and his resignation introduces a degree of unpredictability regarding future regulatory standards.

In light of the FDA’s recent shakeup, H.C. Wainwright anticipates a stricter safety and efficacy benchmark for genetic medicines. This could necessitate more comprehensive clinical trials before regulatory approvals are granted. Consequently, the firm has raised its discount rate for Metagenomi to 14% from the prior 12%, signaling increased investment risk.

The performance of Metagenomi stock has been notably weak compared to the broader market, with a decline of 87% over the past year, which contrasts sharply with the 11% drop in the XBI biotech index. InvestingPro analysis shows the company maintains a strong balance sheet with more cash than debt, though its Financial Health Score of 1.7 indicates underlying challenges. Want deeper insights? InvestingPro offers 15+ additional tips about MGX’s financial position. However, Metagenomi’s trajectory has been similar to that of other gene editing companies, such as Editas Medicine (NASDAQ:EDIT), during the same period.

Despite the challenges, H.C. Wainwright reaffirms its Buy rating on Metagenomi, suggesting a sustained positive outlook on the company’s potential, albeit with a more conservative valuation in the face of regulatory headwinds. InvestingPro’s Fair Value analysis suggests the stock is currently undervalued, though investors should note the company’s rapid cash burn rate and anticipated sales decline this year.

In other recent news, Metagenomi, Inc. has made a significant advancement in gene editing technology with its compact CRISPR-associated transposase (CAST) system. This system has successfully integrated a large gene into the human genome, marking a potential breakthrough in treating complex genetic diseases. Metagenomi also reported progress in its therapeutic development programs, notably with MGX-001, a potential treatment for hemophilia A. The company has initiated discussions with the FDA and commenced Good Manufacturing Practice activities for MGX-001. Additionally, Metagenomi’s collaboration with Ionis Pharmaceuticals (NASDAQ:IONS) has advanced cardiometabolic disease programs, with all four Wave 1 programs reaching lead optimization. The company plans to nominate development candidates from these programs in 2025. Metagenomi has also announced the appointment of Eric Bjerkholt to its Board of Directors. These developments underscore Metagenomi’s ongoing efforts to advance precision genetic medicines.

This article was generated with the support of AI and reviewed by an editor. For more information see our T&C.

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