Caris validates findings on tumor-infiltrating clonal hematopoiesis

Published 22/07/2025, 13:52
Caris validates findings on tumor-infiltrating clonal hematopoiesis

IRVING, Texas - Caris Life Sciences (NASDAQ:CAI), a precision medicine company with a market capitalization of $7.86 billion, has published data in the New England Journal of Medicine that validates recent findings on tumor-infiltrating clonal hematopoiesis (TI-CH), according to a company press release issued Tuesday. According to InvestingPro data, the company maintains a healthy gross profit margin of 46.71% on revenues of $452.5 million in the last twelve months.

The study analyzed 3,255 matched tumor-blood samples from Caris’ database, confirming that TI-CH is prevalent across solid tumors. The highest incidence was found in non-small cell lung cancer, affecting approximately one in four patients (23%).

The research showed that patients with TI-CH have worse outcomes, with a 30% higher risk of death compared to patients without the condition. TI-CH involves blood-derived mutations that infiltrate tumor tissue and can be misinterpreted as tumor-specific mutations, potentially leading to inappropriate treatment decisions.

"The ability to validate important studies shows how collaboration between Caris scientists and a Caris Precision Oncology Alliance member can quickly respond to and confirm new discoveries," said David Spetzler, President of Caris, in the statement.

George W. Sledge, Jr., Caris EVP and Chief Medical Officer, added that understanding clonal hematopoietic mutations’ role in treatment response could lead to improved patient outcomes.

Caris Life Sciences describes itself as a precision medicine company that uses comprehensive molecular profiling and artificial intelligence technologies to analyze disease complexity. The company is headquartered in Irving, Texas, with additional offices in Phoenix, New York, Cambridge, Tokyo, and Basel.

In other recent news, Caris Life Sciences has been the subject of several analyst initiations, highlighting the company’s financial and strategic outlook. Wolfe Research initiated coverage with an Outperform rating and a price target of $32.00, emphasizing Caris Life Sciences’ potential for substantial revenue growth in the coming years. Evercore ISI also rated the company as Outperform, with a slightly higher price target of $33.00, driven by expectations of a 40% compound annual growth rate over the next three years. Citi provided a Buy rating, setting a price target of $34.00, and noted Caris Life Sciences’ unique financial profile and the success of its commercial products, which generated $412 million in total sales for fiscal year 2024. TD Cowen followed suit with a Buy rating and a $32.00 price target, citing potential for further upside despite the stock’s strong early performance. JPMorgan initiated coverage with an Overweight rating and a price target of $31.00, recognizing Caris Life Sciences as a leader in diagnostics and precision medicine. These recent developments reflect a positive consensus among analysts regarding Caris Life Sciences’ future prospects.

This article was generated with the support of AI and reviewed by an editor. For more information see our T&C.

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