Cybin advances Phase 3 trial for depression treatment

Published 23/04/2025, 12:38
Cybin advances Phase 3 trial for depression treatment

TORONTO - Cybin Inc. (NYSE American:CYBN) (Cboe CA:CYBN), a neuropsychiatry company focusing on psychedelic therapies with a market capitalization of $148.3 million, has announced the expansion of its strategic partnership agreements to 18 clinical sites in the United States. According to InvestingPro analysis, the company maintains a strong liquidity position with a current ratio of 12.6, though it’s currently experiencing rapid cash burn as it advances its clinical programs. The stock appears undervalued based on InvestingPro’s Fair Value assessment. These partnerships are part of Cybin’s multinational Phase 3 program, which is evaluating CYB003, a proprietary psilocin-based therapy, as an adjunctive treatment for Major Depressive Disorder (MDD). The program, known as the PARADIGM program, is currently in the APPROACH study phase and is expected to grow to approximately 45 clinical sites.

The company’s Chief Executive Officer, Doug Drysdale, highlighted the benefits of the strategic partnership agreements, stating that they leverage the expertise of each site to ensure consistent sharing of protocols and best practices. With analysts maintaining a strong buy consensus and InvestingPro identifying several key financial indicators, subscribers can access additional insights about Cybin’s development trajectory and financial health metrics. This collaborative approach aims to streamline trial operations and potentially reduce the time to trial completion. Drysdale also expressed satisfaction with the participation of key figures such as Kimball A. Johnson, M.D., and Paul Thielking, who bring significant experience in neuropsychiatric drug trials.

Cybin’s CYB003 has shown promise in Phase 2 trials, where two 16 mg doses administered three weeks apart resulted in a 71% remission rate from depression symptoms over 12 months in patients with MDD. The company continues patient dosing in the APPROACH study and anticipates the second Phase 3 study, EMBRACE, to begin in mid-2025.

The company, founded in 2019, also has CYB004 in a Phase 2 study for generalized anxiety disorder and a pipeline of investigational compounds focused on the 5-HT receptor.

This news is based on a press release statement and includes forward-looking statements, which involve risks and uncertainties. The future results of the company’s drug development programs may differ from current expectations. The forward-looking statements in the press release are based on the company’s management’s assumptions and estimates at the time such statements were made. Cybin makes no medical claims about its proposed products, and their efficacy has not been confirmed by approved research. Regulatory approvals and rigorous scientific research and clinical trials are necessary for the commercialization of the company’s products.

The information in this article is derived from a press release by Cybin Inc. and does not include personal opinions or recommendations. For comprehensive financial analysis and detailed metrics, including 7 additional ProTips and extensive financial data, explore InvestingPro’s complete coverage of Cybin Inc.

In other recent news, Cybin Inc. has been the subject of multiple analyst updates following its latest financial and clinical developments. H.C. Wainwright recently adjusted its price target for Cybin to $150 from $190, maintaining a Buy rating despite the revision. This change reflects a revised timeline for the commercial launch of CYB004, aimed at treating generalized anxiety disorder (GAD), now expected in fiscal year 2028. Meanwhile, Canaccord Genuity also revised its price target for Cybin, lowering it to $73 from $86, while continuing to support the stock with a Buy rating. This adjustment accounts for increased research and development costs and a planned capital raise in mid-2025.

Cybin’s ongoing clinical trials are critical to its future prospects, with the company advancing its CYB003 program into a pivotal Phase 3 stage for major depressive disorder (MDD). Analysts at H.C. Wainwright project that upcoming results from the Phase 2a trial for CYB004 will confirm its safety and efficacy, potentially advancing it to Phase 3 trials. Canaccord’s analysis highlights the company’s financial strategies, including a $100 million at-the-market offering program and anticipated fundraising efforts. Despite these financial recalibrations, analysts express confidence in Cybin’s potential to progress its psychedelic-based treatments through the clinical pipeline.

This article was generated with the support of AI and reviewed by an editor. For more information see our T&C.

Latest comments

Risk Disclosure: Trading in financial instruments and/or cryptocurrencies involves high risks including the risk of losing some, or all, of your investment amount, and may not be suitable for all investors. Prices of cryptocurrencies are extremely volatile and may be affected by external factors such as financial, regulatory or political events. Trading on margin increases the financial risks.
Before deciding to trade in financial instrument or cryptocurrencies you should be fully informed of the risks and costs associated with trading the financial markets, carefully consider your investment objectives, level of experience, and risk appetite, and seek professional advice where needed.
Fusion Media would like to remind you that the data contained in this website is not necessarily real-time nor accurate. The data and prices on the website are not necessarily provided by any market or exchange, but may be provided by market makers, and so prices may not be accurate and may differ from the actual price at any given market, meaning prices are indicative and not appropriate for trading purposes. Fusion Media and any provider of the data contained in this website will not accept liability for any loss or damage as a result of your trading, or your reliance on the information contained within this website.
It is prohibited to use, store, reproduce, display, modify, transmit or distribute the data contained in this website without the explicit prior written permission of Fusion Media and/or the data provider. All intellectual property rights are reserved by the providers and/or the exchange providing the data contained in this website.
Fusion Media may be compensated by the advertisers that appear on the website, based on your interaction with the advertisements or advertisers
© 2007-2025 - Fusion Media Limited. All Rights Reserved.