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LOS ANGELES - Kairos Pharma Ltd. (NYSE American: KAPA), a clinical stage biopharmaceutical company with a market capitalization of $9.91 million, has presented new data on its investigational cancer drug KROS101 at the American Society of Clinical Oncology (ASCO) 2025 Annual Meeting, which concluded today in Chicago. According to InvestingPro analysis, the company’s stock, currently trading at $0.59, is fairly valued based on its proprietary Fair Value model. The study findings suggest that KROS101, a small molecule GITR ligand agonist, has the potential to enhance immune responses against tumor cells.
During the meeting, researchers shared results indicating that KROS101 could promote the proliferation and cytotoxicity of T effector cells, crucial components of the immune system. The drug appears to increase cytokine production and improve the immune system’s ability to target and kill cancer cells. Additionally, the data showed a reduction in T reg-mediated suppression, which could reverse immune system suppression and boost effector T cell activity.
The study also compared KROS101 with TRX518, another anti-GITR antibody previously in clinical trials, and found that KROS101 was superior in several aspects, including T cell tumor infiltration and preventing T cell exhaustion. While the clinical results appear promising, InvestingPro data shows the company maintains strong liquidity with a current ratio of 7.52 and holds more cash than debt on its balance sheet, providing financial flexibility for continued research and development.
John Yu, M.D., CEO of Kairos Pharma, stated, "These results strongly support continued study of KROS101 as a cancer immunotherapy." He emphasized the dual mechanism of action of KROS101 and its potential to contribute significantly to cancer treatment options.
Kairos Pharma is known for its focus on oncology therapeutics and is currently conducting Phase 2 and Phase 1 clinical trials for its lead candidate, ENV105, an antibody targeting CD105 to overcome drug resistance and immune suppression in cancer.
The information presented is based on a press release statement and reflects ongoing research and clinical trials by Kairos Pharma. It should be noted that these findings are preliminary and further studies are required to validate the efficacy and safety of KROS101. As with all clinical research, outcomes from future studies may differ from the initial results. Analyst price targets for KAPA range from $4 to $12, suggesting significant upside potential if clinical trials succeed. Get access to 8 additional exclusive InvestingPro Tips and comprehensive financial analysis by subscribing to InvestingPro.
In other recent news, Kairos Pharma has made significant strides in its clinical trials and financial arrangements. The company is advancing its lead drug, ENV105, through Phase 2 trials for prostate cancer and Phase 1 trials for lung cancer, supported by a $876,000 grant from the U.S. Department of Defense. This funding will aid in identifying biomarkers for lung cancer patients resistant to existing treatments. Kairos Pharma has expanded its prostate cancer trial sites to include the University of Utah and City of Hope. In another development, H.C. Wainwright has maintained its Buy rating on Kairos Pharma with a $12 price target, citing the potential of the company’s oncology pipeline. The firm highlights the importance of upcoming interim data from the ENV105 trials as a significant catalyst for the company. Additionally, Kairos Pharma has appointed Weinberg and Company, P.A. as its new auditor, concluding its relationship with Marcum LLP. Despite economic challenges, the company reports financial stability, bolstered by private placements and non-dilutive funding.
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