Merck to present new HIV prevention and treatment data at IAS 2025

Published 08/07/2025, 11:56
Merck to present new HIV prevention and treatment data at IAS 2025

RAHWAY, N.J. - Pharmaceutical giant Merck (NYSE:MRK), with a market capitalization of $203 billion and impressive 77% gross profit margin, will present new data from its HIV research pipeline at the 13th International AIDS Society Conference on HIV Science taking place July 13-17 in Kigali, Rwanda, according to a press release statement. As a prominent player in the pharmaceuticals industry, Merck continues to demonstrate strong financial health, according to InvestingPro analysis.

The presentations will include Phase 2 data on MK-8527, an investigational once-monthly oral drug for HIV prevention, and findings from three Phase 3 trials examining how preexisting resistance-associated mutations affect virologic response to doravirine/islatravir. With annual revenues of $63.9 billion and currently trading below its Fair Value according to InvestingPro analysis, Merck maintains a strong position to advance its research initiatives.

Merck will also share data from its development program for a once-weekly oral combination of islatravir and ulonivirine for HIV-1 treatment. Based on results from Phase 1 and Phase 2b trials, the company is advancing a once-weekly oral combination of islatravir (2mg) and ulonivirine (200mg), known as MK-8591B, in clinical development.

"With daily, weekly and monthly oral regimens in development, we aim to offer choices that can help address the evolving needs of individuals living with or impacted by HIV," said Dr. Elizabeth Rhee, vice president of global clinical development at Merck Research Laboratories, in the statement.

The company will host a policy symposium on HIV prevention on Tuesday, July 15, and a medical symposium covering HIV treatment considerations on Wednesday, July 16. Both events will be open to registered conference attendees.

Separately, Merck will hold a virtual investor event on Thursday, July 17, where scientific and commercial leaders will provide an overview of the company’s advancing HIV research pipeline.

Merck has been involved in HIV research for more than 35 years, developing treatments across multiple drug classes and working on prevention options aimed at reducing the global burden of HIV infection.

In other recent news, Merck has made significant strides with its pharmaceutical offerings. The U.S. Food and Drug Administration has granted priority review for Merck’s supplemental application to update the label for WINREVAIR, a treatment for pulmonary arterial hypertension (PAH), based on successful results from the Phase 3 ZENITH trial. The trial showed a 76% reduction in risk for severe health events compared to placebo. Additionally, Merck’s WINREVAIR has shown positive results in the Phase 3 HYPERION study, reinforcing its efficacy in treating PAH.

Merck’s vaccine portfolio also sees promising developments as the Advisory Committee on Immunization Practices (ACIP) recommended ENFLONSIA, a preventive treatment for respiratory syncytial virus (RSV) in infants. This recommendation includes its inclusion in the Vaccines for Children Program, enhancing access to this treatment. UBS has reiterated its Buy rating on Merck, highlighting Gardasil and Keytruda as key revenue drivers, although the competitive landscape in China poses challenges.

TD Cowen maintained a Hold rating on Merck following an influential ACIP vote for the Enflonsia vaccine, suggesting potential new market opportunities. Analysts at Morgan Stanley have maintained an Equalweight rating on Merck, with optimism about the cardiometabolic franchise’s growth potential, raising peak sales guidance to approximately $15 billion. These developments underscore Merck’s ongoing efforts to expand its pharmaceutical and vaccine offerings.

This article was generated with the support of AI and reviewed by an editor. For more information see our T&C.

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