PharmaMar FY 2024 slides: Revenue up 11%, net profit soars amid clinical advances

Published 04/07/2025, 10:10
PharmaMar FY 2024 slides: Revenue up 11%, net profit soars amid clinical advances

Introduction & Market Context

Spanish biopharmaceutical company PharmaMar presented its full-year 2024 results on February 28, 2025, highlighting significant financial improvements and clinical development milestones. The company, which specializes in marine-derived oncology treatments, reported substantial revenue growth and a dramatic increase in profitability while advancing its pipeline of cancer therapies.

Financial Performance Highlights

PharmaMar reported total revenues of €174.9 million for fiscal year 2024, representing an 11% increase from €158.2 million in 2023. The company’s recurring revenues grew by 3% to €127.9 million, while non-recurring revenues increased to €47.0 million from €34.1 million in the previous year.

As shown in the following revenue breakdown chart:

The company’s revenue mix remained relatively stable, with Zepzelca accounting for 31% of total revenues and Yondelis representing 69% in 2024. Oncology sales showed strong performance, increasing by 17.6% to €61.3 million compared to €52.2 million in 2023.

PharmaMar’s profitability metrics showed remarkable improvement, with net profit surging to €26.1 million in 2024 from just €1.1 million in 2023. The company also achieved positive operating profit of €6.5 million, reversing the previous year’s operating loss of €3.8 million.

The following table details the key financial metrics:

Despite a 7.4% decrease in product sales to €66.5 million, PharmaMar saw significant growth in licensing agreements, which increased by 38.5% to €46.5 million. The company maintained its commitment to research and development, increasing R&D expenditure by 4.2% to €103.5 million.

PharmaMar ended 2024 with a strong balance sheet, reporting €157 million in cash and cash equivalents against total financial debt of €47.8 million. The company generated €6.0 million in operating cash flow during the year.

Clinical Development Progress

PharmaMar’s oncology pipeline continues to advance across multiple indications, with particular focus on its lead compounds Yondelis, Zepzelca, and newer candidates like Ecubectedin, PM534, and PM54.

The comprehensive pipeline overview illustrates the company’s development strategy:

A significant milestone for PharmaMar in 2024 was the positive results from the IMforte Phase 3 clinical trial, which evaluated the combination of lurbinectedin (Zepzelca) and atezolizumab in small cell lung cancer patients. The trial demonstrated statistically significant and clinically meaningful improvements in both overall survival and progression-free survival.

Based on these results, PharmaMar plans to submit a marketing authorization application to the European Medicines Agency in the first half of 2025, while its partner Jazz Pharmaceuticals (NASDAQ:JAZZ) will submit a supplemental New Drug Application to the FDA.

The company outlined a clear regulatory pathway for lurbinectedin in the European market, with expected EU marketing authorization in the first half of 2026 and subsequent market launch in the second half of 2026 based on the IMforte trial results.

Strategic Initiatives and Future Outlook

PharmaMar’s clinical development strategy focuses on three key pillars for sustainable growth: advancing Ecubectedina (PM14), developing PM54 as a potential second-generation lurbinectedin, and progressing PM534, a novel tubulin inhibitor showing early signs of activity in solid tumors.

The company’s long-term value creation strategy encompasses three main areas: lurbinectedin development, advancing other drug candidates, and corporate development initiatives. PharmaMar aims to leverage its strong balance sheet to pursue in-licensing opportunities while continuing to develop and commercialize its internal pipeline.

PharmaMar also highlighted its commitment to environmental, social, and governance (ESG) initiatives during 2024, including the publication of its Sustainability Report, approval of Human Rights and Biodiversity policies, and implementation of a Net Zero Plan for decarbonization by 2050.

Forward-Looking Statements

Looking ahead, PharmaMar is positioned for potential growth catalysts with its lurbinectedin regulatory submissions and ongoing clinical trials. The company’s global commercialization strategy includes direct marketing in Western European territories and partnerships for other regions, creating a diversified approach to maximize the value of its oncology portfolio.

The company’s robust cash position provides financial flexibility to support both pipeline advancement and potential business development opportunities, while its focus on novel marine-derived compounds offers a differentiated approach in the competitive oncology market.

With multiple clinical readouts expected in the coming years and a clear regulatory pathway for its lead asset, PharmaMar appears well-positioned to build on its 2024 financial performance and advance its mission of developing innovative cancer treatments derived from marine organisms.

Full presentation:

This article was generated with the support of AI and reviewed by an editor. For more information see our T&C.

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