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Investing.com -- Tourmaline Bio, Inc. (NASDAQ:TRML) stock fell 3% after the company announced positive topline results from the Phase 2 TRANQUILITY trial evaluating pacibekitug in patients with elevated high-sensitivity C-reactive protein (hs-CRP) and chronic kidney disease (CKD). Despite the reported success in the trial, the market response was negative.
The TRANQUILITY trial demonstrated that pacibekitug, an IL-6 inhibitor, provided rapid, deep, and durable reductions in hs-CRP, with high statistical significance over placebo. Moreover, pacibekitug is the first IL-6 inhibitor to show such results with quarterly dosing in a clinical trial. The overall incidence rates of adverse events and serious adverse events were comparable to placebo, suggesting a favorable safety profile.
Tourmaline’s CEO, Sandeep Kulkarni, expressed optimism about the data and the potential for pacibekitug to advance into Phase 3 trials for atherosclerotic cardiovascular disease and a planned Phase 2 trial for abdominal aortic aneurysm. The company plans to share additional data at an upcoming medical conference.
The TRANQUILITY trial, which included participants with elevated hs-CRP and CKD stages 3 or 4, aimed to evaluate the efficacy of pacibekitug in reducing hs-CRP, a biomarker associated with cardiovascular risk. The trial’s primary endpoint was the median time-averaged percent change in hs-CRP through Day 90.
The biotech firm has future plans to advance pacibekitug’s development in cardiovascular inflammation and assess Phase 3 trial designs in patients with atherosclerotic cardiovascular disease. Additionally, a Phase 2 proof-of-concept trial for abdominal aortic aneurysm is expected to commence in the second half of 2025.
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