Earnings call transcript: Brainstorm Cell Therapeutics Q4 2024 highlights cost-cutting

Published 31/03/2025, 14:22
 Earnings call transcript: Brainstorm Cell Therapeutics Q4 2024 highlights cost-cutting

Brainstorm Cell Therapeutics Inc. (BCLI) reported its financial results for the fourth quarter of 2024, highlighting significant cost reductions and strategic shifts in its operational focus. The company’s stock closed at $1.19, reflecting an 11.85% decline in the regular session, with no change in premarket trading. According to InvestingPro data, the stock has declined nearly 86% over the past year, with a current market capitalization of just $6.79 million. Technical indicators suggest the stock is currently in oversold territory. The company is concentrating on its Phase 3b trial for Neuron, an investigational ALS treatment, amid a challenging market for non-revenue biotech firms.

Key Takeaways

  • Brainstorm Cell Therapeutics reduced its research and development expenses significantly from $10.7 million in 2023 to $4.7 million in 2024.
  • The company reported a net loss of $11.6 million for 2024, a reduction from the $17.2 million loss in 2023.
  • Cash reserves fell to $400,000 by the end of 2024, down from $1.5 million the previous year.
  • The company is advancing its Neuron ALS treatment, securing a Special Protocol Assessment with the FDA.

Company Performance

Brainstorm Cell Therapeutics has been navigating a difficult period, characterized by a reduction in expenses and strategic realignment towards its Neuron ALS treatment. The company’s efforts to streamline operations have resulted in significant cost savings. Despite these measures, the net loss remains substantial, indicating ongoing financial challenges. InvestingPro analysis reveals a concerning financial health score of 1.46 (WEAK), with 12 additional key insights available to subscribers. The company’s current ratio of 0.05 indicates significant liquidity challenges, with short-term obligations exceeding liquid assets.

Financial Highlights

  • Research and Development Expenditures: $4.7 million, down from $10.7 million in 2023.
  • General and Administrative Expenses: $7 million, down from $10.7 million in 2023.
  • Net Loss: $11.6 million, compared to $17.2 million in 2023.
  • Cash and Equivalents: $400,000 as of December 2024, down from $1.5 million in 2023.

Outlook & Guidance

Looking ahead, Brainstorm Cell Therapeutics plans to initiate its Phase 3b trial for Neuron in 2025, targeting early-stage ALS patients. The company anticipates needing $20-30 million annually to fund the trial and is exploring non-dilutive financing options, such as grants. While analyst price targets range from $9.00 to $24.35, suggesting significant upside potential, InvestingPro’s comprehensive analysis, available in the Pro Research Report, provides deeper insights into the company’s valuation and growth prospects among 1,400+ US stocks. The goal is to generate robust data to support a potential Biologics License Application (BLA) submission.

Executive Commentary

CEO Chaim Levowitz emphasized the company’s pioneering role in ALS treatment, stating, "We are pioneering in a space where we know there is skepticism and we must provide robust data to validate Neuron’s efficacy." Chief Medical Officer Dr. Bob Dagher added, "This trial is designed to provide definitive evidence of Neuron’s efficacy."

Risks and Challenges

  • Financial Health: With dwindling cash reserves, securing additional funding is critical.
  • Regulatory Hurdles: Navigating FDA requirements poses potential delays.
  • Market Competition: Increasing competition in the biotech sector could impact market share.
  • Operational Costs: Continuing cost control measures are essential to maintain financial stability.

Brainstorm Cell Therapeutics is focused on overcoming these challenges through strategic partnerships and cost-effective operations, while maintaining its commitment to developing innovative ALS treatments.

Full transcript - Brainstorm Cell Therapeutics Inc (BCLI) Q4 2024:

Conference Operator: Good morning, everyone, and welcome to Brainstorm Cell Therapeutics Fourth Quarter twenty twenty four Earnings Call. At this time, all participants are in a listen only mode. Please note this conference is being recorded. I will now turn the conference over to your host, Michael Wood. Michael, the floor is yours.

Michael Wood, Host/Moderator, Brainstorm Cell Therapeutics: Thank you, operator. Good morning and thank you for joining us. Before passing it off to company management for prepared remarks, I’d like to remind listeners on this conference call that it will contain numerous statements, descriptions, forecasts and projections regarding Brainstorm Cell Therapeutics and its potential future business operations and performance statements regarding the market potential of the treatment for neurodegenerative disorders such as ALS, the sufficiency of the company’s existing capital resources for continuing operations in 2025 and beyond, the safety and clinical effectiveness of the Neuron technology platform, clinical trials of Neuron and related clinical development programs and the company’s ability to develop strategic collaborations and partnerships to support their business planning efforts. Forward looking statements are subject to numerous risks and uncertainties, many of which are beyond the Brainstorm’s control, including the risks and uncertainties described from time to time in the company’s SEC filings. The company’s results may differ materially from those projected on today’s call, and they undertake no obligation to publicly update any of these forward looking statements.

Joining us on the call today will be Mr. Chaim Levowitz, President and CEO of Brainstorm and Alla Patilist, Interim Chief Financial Officer And in addition, Doctor. Haro Hartonian, EVP and Chief Operating Officer and Doctor. Bob Dagher, EVP and Chief Medical Officer are also on the line and they will be available for the Q and A. So with that, I’d like to turn the call over to Mr.

Liebowitz. Please go ahead.

Chaim Levowitz, President and CEO, Brainstorm Cell Therapeutics: Thank you, Michael. Good morning, good afternoon to everyone. Thank you for joining us today. We appreciate your continued interest and support in BRAINSTORM. Twenty twenty four was a year of foundational work, positioning us for the critical Phase 3b trial of Neuron, our investigational treatment for ALS.

Our team in close collaboration with leading ALS experts and regulatory authorities has carefully designed a trial aimed at confirming Neurone’s potential to significantly slow disease progression in early stage patients, thus generating the robust data necessary for successful biologic license application. Our primary focus for 2025 is clear and unwavering execution. We’re now advancing preparations to initiate the trial and begin patient enrollment driven by our strong belief that Neuron, if approved, can make a meaningful difference in the lives of ALS patients. I want to address today three key areas critical to our progress regulatory, clinical and trial execution and manufacturing. Regulatory, we maintain a strong collaborative relationship with the FDA.

In 2024, we secured a special protocol assessment, significantly derisking the regulatory pathway. We’re also aligned with the FDA on chemistry, manufacturing and controls, a crucial aspect for a complex cell therapy like Neuron. I want to emphasize that we have been diligently updating and submitting models to our IND application, including detailed technical transfer documentation, quality assurance and quality control processes. While these processes require attention and time, they are essential for regulatory compliance and trial integrity. We anticipate announcing the submission of these models shortly.

Clinical. We are in active negotiations for clinical trial agreements with approximately 15 leading clinical centers across The United States, leveraging our established relationship with many of these institutions. The strong interest from the known ALS clinicians and researchers underscore their belief in Neurom’s potential. We will announce these agreements as they are finalized. The trial execution and manufacturing to ensure the efficient execution of our Phase 3b trial, we have partnered with Acquivia, a leading clinical research organization, specializing in cell and gene therapy trials.

Equivia’s expertise in ALS trials, regulatory compliance and comprehensive capabilities will be crucial in managing key aspects of the clinical trial. For the clinical manufacturing of Neuron, we have contracted with Pluri Inc, leveraging their expertise in GMP compliant production. This arrangement complements our leased facility at Sarafsky Medical Center in Tel Aviv. Furthermore, we’re planning to bring an additional U. S.

Based manufacturing center online to support broader production needs as we advance through clinical trials. Our financial position and strategic outlook. I want to address the financial realities as a future direction of Brainstorm directly. We are committed to securing the necessary funding, execute the Phase 3b trial and build a sustainable future. We’re actively pursuing multiple funding avenues, including what we announced today, including licensing non core assets for near term capital and exploring non dilutive financing opportunities such as grant fundings.

I understand that investors and even more so the patient community are eager for rapid progress. We are accurately aware of the urgency. I want to acknowledge the extraordinary dedication of our staff who worked tirelessly under significant financial constraints, including salary reductions to advance this trial. The time required for regulatory submissions including the intricate technical transfer and QA QC processes inherent in a pioneering stem cell therapy is not indicative of financial delays. I also want to address the expectations regarding immediate financial announcing announcements and trial milestones.

We’re committed to transparency, but we must adhere the rigorous regulatory processes. We’re pioneering in a space where we know there is skepticism and we must provide robust data to validate neurons efficacy. The Phase 3b trial involves rolling enrollment based on manufacturing capabilities for an autologous stem cell therapy. And we anticipate needing approximately $20,000,000 to $30,000,000 annually to see the trial to its conclusion. Given our current market capitalization and the challenging market for non revenue biotech, raising this amount of cash upfront is not practical.

But we believe that as we achieve key milestones, IND model submission, FDA clearance to proceed, signing CTAs and enrolling the first patient, we will see a corresponding increase in our market valuation, especially when combined with strategic partnership and under little grants. We are fully committed to this mission. Myself, our Chief Medical Officer, our Chief Operating Officer, our Chief Business Officer and other senior officers are refines working without remuneration. And most of our other employees have taken significant reductions in compensation. Many of our talented team members have also made sacrifices.

They are driven by a shared commitment to proving Neuron’s potential and ultimately helping ALS patients and for other neurodegenerative disease. We are deeply grateful for their dedication and want to assure they are recognized and rewarded for their contributions. ALS is a devastating disease. We are committed to providing a therapeutic solution. We are confident in the foundation we have built and the progress we are making.

We will continue to provide updates as we advance through the Phase 3b trial. We are committed to doing all we can to make this happen. Thank you for your continued support. I’ll now turn the call over to Alla, Serbida Financials.

Alla Patilist, Interim Chief Financial Officer, Brainstorm Cell Therapeutics: Thank you, Chaim. Research and development expenditures net for the year ended 12/31/2024, were DKK 4,700,000.0. This compares to DKK 10,700,000.0 for the year ended 12/31/2023. General and administrative expenses for the twelve months ended 12/31/2024, were approximately $7,000,000 compared with $10,700,000 in 2023. Net loss for the twelve months ended 12/31/2024 was approximately $11,600,000 or $2.31 per share.

This compares with a net loss of approximately $17,200,000 dollars or $6 per share for the twelve months ended 12/31/2023. Cash, cash equivalents and restricted cash were approximately $400,000 as of the December 2024 compared to EUR 1,500,000.0 as of the December 2023. The company is announcing today that they have entered into warrant inducement agreement, pursuant to which we expect to raise approximately SEK 1,640,000.00 in growth proceeds. This agreement is expected to close on or about 04/01/2025. I will now turn the call back to Haim.

Chaim Levowitz, President and CEO, Brainstorm Cell Therapeutics: Thank you. Michael, do you want to read the questions the prepared questions?

Michael Wood, Host/Moderator, Brainstorm Cell Therapeutics: Yes, Haim. First question here. Some investors are concerned about the delays initiating the Phase 3b trial. Can you please provide more clarity on the timeline and the reasons for the perceived delays?

Chaim Levowitz, President and CEO, Brainstorm Cell Therapeutics: Thank you, Michael. As I said, we understand the urgency and frustration regarding the trial timeline. We share that frustration, but while we are moving as quickly as possible, pioneering a complex cell therapy like Neuron requires stringent adherence to regulatory processing. The perceived delays are primarily due to the intricate and time consuming nature of updating and submitting the necessary model to the IND. That includes technical transfer, quality assurance, quality control documentation.

These are not simply administrative tasks. They involve complex scientific and manufacturing processes that require rigorous validation. Additionally, the negotiation and finalization of clinical trial agreements with multiple sites take time. The period between our NASDAQ non compliance announcement and the grant of the extension also created the challenging financial environment. We are now focused on finalizing these agreements and initiating patient enrollment as quickly as possible.

We anticipate announcing the IND model submission shortly, which will be an important milestone.

Michael Wood, Host/Moderator, Brainstorm Cell Therapeutics: Next question, can you elaborate on the financial situation and how you plan to secure the necessary funding for the trial?

Chaim Levowitz, President and CEO, Brainstorm Cell Therapeutics: Yes. Thank you, Michael, for that one. We’re actively pursuing multiple funding avenues to ensure the successful execution of our Phase 3b trial. This morning, we announced a significant step in bolstering our financial position raising approximately $1,640,000 through warrant inducement, demonstrating investor confidence in our strategy. As mentioned, we’re also exploring the licensing of non core assets for near term capital.

We’re also focusing on securing non dilutive financing through grant opportunities, a strategy that has proven successful for us in the past. Notably, we received a CIRM grant of approximately $60,000,000 for our Phase III trial. We anticipate needing approximately $23,000,000 annually for the trial. Given the current market conditions, particularly for non revenue biotech companies, as I said in my remarks, raising all funds upfront is not realistic. We are confident that as we achieve Hema’s count, such as the IND model submissions, CTA signings and the raw material of the first patient, our market valuation will improve, making it easier to secure additional funding.

We’re also open and proceeding strategic partnerships that can provide financial and operational support. Thank you.

Michael Wood, Host/Moderator, Brainstorm Cell Therapeutics: Next question. Some analysts and investors are skeptical about the efficacy of Neuron. How do you plan to address these concerns?

Chaim Levowitz, President and CEO, Brainstorm Cell Therapeutics: Yes. Thank you. Bob, would you take this question?

Dr. Bob Dagher, EVP and Chief Medical Officer, Brainstorm Cell Therapeutics: Sure. Thank you for the question. As we all know, there has been a lot of thought and progress and design changes and agreements with FDA on the next path for Neuron. Under the Special Protocol Assessment Agreement, we have made it clear that we are pursuing the right population that is target for our therapy with the most success and data generated from previous trials. The choice of the endpoints, the duration of the trial, the critical design elements of this have de risked our program significantly and hence we feel strongly about our probability of success this next time around with this landmark Phase TB trial that we are embarking on initiating and completing.

This trial is designed to provide definitive evidence of Neurons efficacy. And I emphasize definitive. We are really focused on what it’s going to take to make sure that we demonstrate the therapeutic effect of MURON under the regulatory constraints and all the elements in place needed provided that the data comes positive that we will be filing our BLA and support approval for our therapy. It’s also important to note that many of the leading key opinion leaders in ALS that we consult with them all the time. We’re constantly in contact with them.

Many have served as principal investigators of previous Phase three trial, strongly believe in neuron potential having seen and having been close to the data and worked with patients who were given our therapy in the past. I particularly emphasize in the early stage of the patient population. This disease we have to basically put in place all the parameters to enroll the population that will benefit most from this treatment and the evidence is there. So we feel very strong about that. Also we have received very strong support from many neurologists, scientists, advocacy groups, the patients themselves.

So yes, this skepticism we acknowledge it exists, but we’re committed to providing the data, the sites of data that will basically speak for itself at the end of the day. Thank you, Michael.

Michael Wood, Host/Moderator, Brainstorm Cell Therapeutics: Thank you, Bob. And next question, what is the status of the manufacturing facilities and how will you ensure a consistent supply of Neurone?

Chaim Levowitz, President and CEO, Brainstorm Cell Therapeutics: Thank you. I will ask Harald to respond to the question.

Dr. Harald Hartonian, EVP and Chief Operating Officer, Brainstorm Cell Therapeutics: Thank you, Michael, for the question. As discussed in the prepared remarks, we have established a robust manufacturing strategy to support the Phase IIIb trial and future commercialization. We have contracted with Pluri Inc. For clinical manufacturing, leveraging their expertise in GMP compliant production. This complements our leased facility at Sorsky Medical Center in Tel Aviv.

We are also planning to bring an additional U. S. Based manufacturing center online to support broader production needs. Our internal teams and partners remain focused on meeting all CMC requirements. This multifaceted approach will ensure a consistent and reliable supply of Neuron for the trial and behind.

Michael Wood, Host/Moderator, Brainstorm Cell Therapeutics: Thank you, Haro. Next question. Given the current financial constraints, how is the company ensuring operational continuity and maintaining its commitment to starting the Phase IIIb trial?

Chaim Levowitz, President and CEO, Brainstorm Cell Therapeutics: Thank you, Michael. We understand the importance of maintaining operational continuity and delivering on our commitment to the Phase IIIb trial. Despite the financial challenges, our team remains deeply dedicated and focused. We’ve implemented strategic cost saving measures, including salary reductions for many and periods during which members of our senior leadership have worked without compensation to prioritize the trial’s progress. Our staff consists of highly skilled and experienced professionals who are passionate about bringing Neurone to ALS patients.

Their dedication is a testament to their belief in the potential of this therapy. We’re confident in our ability to navigate these challenges and advance the trial activity. We are committed to ensuring that the team’s dedication will be recognized and awarded as we achieve our milestones.

Michael Wood, Host/Moderator, Brainstorm Cell Therapeutics: Thank you. And one final submitted question here. Why don’t you just refile the original BLA?

Chaim Levowitz, President and CEO, Brainstorm Cell Therapeutics: Refiling the BLA at this time would not in our best opinion be the most strategic path forward. We are focused on generating robust data required by the FDA through the Phase 3b trial according to our SPAC agreement with the FDA. This trial is designed to address specific concerns, raise and provide the evidence necessary to support a new BLA and a successful path to approval. We believe this approach will ultimately lead to a more definitive and sustainable path to bringing neuron to patients. Thank you.

And operator, Jenny, do we have any questions on the line?

Conference Operator: Yes, we do. I’m just going to read the instructions to the audience. If anyone else would like to queue up. So we’ll now be conducting our question and answer session via the phone lines. Thank you.

Your first question is coming from Jason McCarthy of the Maxim Group. Jason, your line is live.

Jason McCarthy, Analyst, Maxim Group: Good morning, Haiyan and team. Thanks for the update. Can you speak, I guess, broadly about your thoughts on the changing environment in the cell therapy space, particularly unmodified cells like Neuron, they’re not genetically manipulated in any way? Since we’ve seen one approval in January, we’re probably going to see another. And while Brainstorm has done tremendous things in getting to SPA and alignment with FDA, the whole environment seems to have changed towards being more favorable to exactly what you’re doing.

And I’m wondering if that opens up avenues of discussion with pharma partners or additional sources of non dilutive capital through grants. Even we have an administration that in their prior administration put that right to try in place and now there’s somebody at HHS that is a big believer in stem cells. How do all these things shape the path forward for Brainstorm Higham?

Chaim Levowitz, President and CEO, Brainstorm Cell Therapeutics: Thank you, Jason. It’s a very good question. And the truth is we try to stay away from the political limelight. We want to stay very focused on the scientific data we want to provide, but to be seen how these different staff changes will have an impact on how the FDA goes forward. But I believe that all parties would support good scientific results.

So I think we timely were able to lock down with FDA a very strong special protocol assessment, which really says that they see merit in our early patient population and they want to ask to replicate that. And that’s where we are going. So while it’s a very tough funding atmosphere, you know how the market is better than me just and you’re an analyst And biotech is not having it easy. I do believe that we are undervalued at the moment. I know many CEOs say that, but really we are after the negative outcome we have.

And people are skeptical if we’re able to pull this off. But I think we’re just now on the verge of pulling it off a few weeks later than we had announced and thought. But we’re very close to signing for a CTA, getting all these models to FDA and the feedback from them. We are in contact with them in a daily basis when needed. And they wanted the trial to start as well.

The rest, we’ll have to follow and see. But I do recognize the fact that the FDA in December approved the first ever mesenchymal stem cells for GVHD. And that’s very good because we are pioneering and pioneering has many challenges. And so it was good that another company went through the challenge and got the first mesenchymal cell therapy approved and hopefully we’re going to be the second.

Jason McCarthy, Analyst, Maxim Group: Right. Thank you. And prior to these approvals, I know Brainstorm the year before went through the adcom, went through a whole series of events. But what’s changed as you know between then and now, I think is how FDA views datasets related to stem cells, obviously far more favorable. And I know the prior question that you had was why don’t you just resubmit the BLA.

I understand that you can’t it’s not the best path forward. But given FDA’s view of these datasets now from what we’ve seen, should the prior Phase three data be used to support the Phase IIIb if you’re able to complete that trial and file a BLA?

Chaim Levowitz, President and CEO, Brainstorm Cell Therapeutics: Yes, definitely we’ll support that part of the pipeline that we’ll take into consideration the previous data. As we said, we want to replicate the early patient population as a result of the Phase III trial. Bobby, you may want to add some comments to that?

Dr. Bob Dagher, EVP and Chief Medical Officer, Brainstorm Cell Therapeutics: Yes. Thanks. Jason, this is a very important question for us, obviously. So as everyone knows, the main reason why we are all here today is because we believe in that data that was generated specifically in the early disease population. There was a pre specified analysis for the population that had a baseline score above 35 panning out to be positive, as well as many post hoc analyses in early disease and all of that data from the previous Phase III trial will support the next Phase IIIb trial specifically in that population.

So the pooling of data will be basically strong support. We totally agree with you. This is the path that we’re taking.

Jason McCarthy, Analyst, Maxim Group: Got it. And last question, I think I heard earlier, there is an ongoing effort to open a manufacturing facility here in The U. S. Is that accurate? And two, what would be the kind of the size and capacity of that center?

And third part, is the discussion with potential investors, is there a hang up on manufacturing that it’s overseas versus not being here in The States? And if so, does this mitigate some of those concerns and reopen those discussions?

Chaim Levowitz, President and CEO, Brainstorm Cell Therapeutics: Well, that was quite a few questions. Thank you for that, Jason. So the answer is that it’s quite clear that towards the end of a trial, you want to have a site that’s ready for inspection of the FDA to get commercialized ASAP if you are successful in the primary results of the trial. So no, there’s no concern from the FDA on the sense that we are providing the trial, but on the other hand, we do want to have ready a stripe that’s ready for inspection. So Harrow and the team are rigorously working, and we will be announcing something very soon.

So the sites that we are looking forward to partner with in The United States. I hope that answers your question.

Jason McCarthy, Analyst, Maxim Group: Yes. Great. Thank you, Hayab.

Chaim Levowitz, President and CEO, Brainstorm Cell Therapeutics: Thank you very much. We have time for one more question. Thank you.

Conference Operator: Yes. Your next question is coming from David Bautz of Zacks Small Cap. David, your line is live.

David Bautz, Analyst, Zacks Small Cap: Hey, good morning, everyone. Thanks for the overview this morning. I just got a couple of follow-up financial questions. Haim, what percentage I don’t know if you can quantitate completely, but what percentage of financing do you want to have in place before you’re comfortable with getting the trial started? And then how quickly after that funding is in place do you think the first patient can be enrolled?

Chaim Levowitz, President and CEO, Brainstorm Cell Therapeutics: It’s a very good question. So the answer is we are working very close with our partners and we’re having those discussions and the partners are giving us a lot of leeway, which is very outstanding and we are very grateful for those partners. It’s not something that’s difficult. I think our partners see the upside of this product, and it’s almost like a mission to get this product into patients. There’s no one else that’s going to do the trials, not brainstorm, and those partners are really partnering with us in an outstanding way.

Having said that, in addition to what we wrote in today, just to be able to start finalize the preparations, we are having, of course, other fundings in the pipeline, which we cannot discuss on this day. But I think once we announce that, everyone will be comfortable with our plan going forward. And that’s in addition to non dilutive grant, which is also in the pipeline for the fall.

David Bautz, Analyst, Zacks Small Cap: Okay. Thanks for taking the question.

Conference Operator: Thank you very much. Well, we appear to have reached the end of our

Chaim Levowitz, President and CEO, Brainstorm Cell Therapeutics: I just want to thank everyone for joining us today and we’re looking forward for the next update. Hopefully, it will be after the first patient and in a different environment for our financial situation as well. Thank you very, very much.

Conference Operator: Thank you very much. This does conclude today’s conference call. You may disconnect your phone lines at this time and have a wonderful day. Thank you for your participation.

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