Crinetics stock holds Overweight rating at Piper Sandler after acromegaly drug approval

Published 08/10/2025, 14:42
Crinetics stock holds Overweight rating at Piper Sandler after acromegaly drug approval

Investing.com - Piper Sandler maintained its Overweight rating and $97.00 price target on Crinetics Pharmaceuticals (NASDAQ:CRNX) following the recent approval of its acromegaly treatment PALSONIFY. According to InvestingPro data, analysts’ targets range from $40 to $143, with the stock currently trading at $42.12.

The research firm noted that Crinetics shares have gained approximately 20% over the past month after PALSONIFY received approval for acromegaly with what it described as a clean, broad label and thoughtful pricing strategy. This aligns with InvestingPro data showing strong returns over both one and three months, with the stock up 66% over the past six months.

Piper Sandler’s analysis suggests expectations heading into the commercial launch are reasonable, with the U.S. acromegaly total addressable market estimated at approximately 36,000 patients, including an initial addressable market of about 11,500 patients.

The firm’s channel checks indicate that key opinion leaders see significant utility for PALSONIFY and expect it could eventually be used in more than 70% of patients with the condition.

Piper Sandler also highlighted that the market may not fully appreciate Crinetics’ commercial infrastructure, which includes the CrinetiCARE program, simplified start form paperwork, and active advocacy support for patients.

In other recent news, Crinetics Pharmaceuticals has seen a series of positive developments following the FDA approval of its acromegaly treatment, Palsonify. Oppenheimer has raised its price target for Crinetics to $87 from $73, maintaining an Outperform rating, attributing the revision to the approval of Palsonify. Similarly, Stifel increased its price target to $75 from $58, noting the drug’s annual price of $290,000 exceeded market expectations. Piper Sandler reaffirmed an Overweight rating with a $97 price target, highlighting the drug’s potential as a "gamechanger" according to a UK endocrinologist. Leerink Partners also raised its target to $88 from $80, citing the drug’s potential to reshape the acromegaly market with its broad label. Morgan Stanley adjusted its price target to $77 from $65, emphasizing the drug’s higher-than-expected list price and broad label. These recent developments underscore the positive reception of Palsonify in the market.

This article was generated with the support of AI and reviewed by an editor. For more information see our T&C.

Latest comments

Risk Disclosure: Trading in financial instruments and/or cryptocurrencies involves high risks including the risk of losing some, or all, of your investment amount, and may not be suitable for all investors. Prices of cryptocurrencies are extremely volatile and may be affected by external factors such as financial, regulatory or political events. Trading on margin increases the financial risks.
Before deciding to trade in financial instrument or cryptocurrencies you should be fully informed of the risks and costs associated with trading the financial markets, carefully consider your investment objectives, level of experience, and risk appetite, and seek professional advice where needed.
Fusion Media would like to remind you that the data contained in this website is not necessarily real-time nor accurate. The data and prices on the website are not necessarily provided by any market or exchange, but may be provided by market makers, and so prices may not be accurate and may differ from the actual price at any given market, meaning prices are indicative and not appropriate for trading purposes. Fusion Media and any provider of the data contained in this website will not accept liability for any loss or damage as a result of your trading, or your reliance on the information contained within this website.
It is prohibited to use, store, reproduce, display, modify, transmit or distribute the data contained in this website without the explicit prior written permission of Fusion Media and/or the data provider. All intellectual property rights are reserved by the providers and/or the exchange providing the data contained in this website.
Fusion Media may be compensated by the advertisers that appear on the website, based on your interaction with the advertisements or advertisers
© 2007-2025 - Fusion Media Limited. All Rights Reserved.