Crinetics Pharmaceuticals, Inc., a clinical-stage pharmaceutical company, focuses on the discovery, development, and commercialization of novel therapeutics for rare endocrine diseases and endocrine-related tumors. The company’s lead product candidate is Paltusotine, an oral selective nonpeptide somatostatin receptor type 2 agonist, which is in a Phase 3 clinical trial for the treatment of acromegaly and carcinoid syndrome associated with neuroendocrine tumors. It is also developing Atumelnant, an investigational oral nonpeptide product candidate to antagonize the adrenocorticotrophic hormone (ACTH) receptor that has completed a Phase 1 study for the treatment of diseases caused by excess ACTH, including congenital adrenal hyperplasia and cushing’s disease; and CRN09682, a nonpeptide drug conjugate for SST2 positive solid tumors. In addition, the company is developing antagonists of the parathyroid hormone (PTH) receptor for the treatment of primary hyperparathyroidism and humoral hypercalcemia of malignancy, and other diseases of excess PTH; thyroid-stimulating hormone receptor antagonists for the treatment of graves’ disease and thyroid eye disease; SST3 Agonist program for the treatment for autosomal dominant polycystic kidney disease; and Radionetics for multiple solid-tumors, as well as Oral GLP-1 and Oral GIP nonpeptides for the treatment of obesity. The company has an agreement with Sanwa Kagaku Kenkyusho Co., Ltd to develop and commercialize Paltusotine in Japan, and Cellular Longevity, Inc. to develop and commercialize CRN01941, a somatostatin receptor type 2 agonist. Crinetics Pharmaceuticals, Inc. was incorporated in 2008 and is headquartered in San Diego, California.
Promising Pipeline | Crinetics' lead candidates paltusotine and atumelnant show potential to revolutionize treatments for acromegaly and congenital adrenal hyperplasia |
Market Expansion | Explore how Crinetics' oral therapies could tap into large untreated patient populations, potentially expanding the acromegaly market beyond current estimates |
Analyst Projections | Delve into analysts' expectations, with price targets ranging from $90 to $97 and projected 2026 revenue of $45 million for paltusotine in acromegaly |
Growth Potential | Learn about Crinetics' multi-indication strategy and its potential to disrupt multiple endocrine disorder markets, with estimated peak sales exceeding $5 billion annually |
Metrics to compare | CRNX | Sector Sector - Average of metrics from a broad group of related Healthcare sector companies | Relationship RelationshipCRNXPeersSector | |
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P/E Ratio | −7.8x | −4.8x | −0.5x | |
PEG Ratio | 0.79 | 0.00 | 0.00 | |
Price/Book | 2.5x | 0.7x | 2.6x | |
Price / LTM Sales | 2,078.4x | 1.5x | 3.3x | |
Upside (Analyst Target) | 123.1% | 104.5% | 40.3% | |
Fair Value Upside | Unlock | 12.3% | 5.1% | Unlock |