Leerink maintains argenx stock Outperform rating and $750 target

Published 09/05/2025, 12:10
Leerink maintains argenx stock Outperform rating and $750 target

On Friday, Leerink Partners maintained their Outperform rating and $750.00 price target for argenx SE (NASDAQ: ARGX), following the company’s first-quarter earnings call. The biotechnology firm’s quarterly worldwide revenues for Vyvgart totaled $790 million, aligning closely with the sell-side consensus estimates of approximately $787.9 million to $784.3 million. With impressive year-over-year revenue growth of 82% and a market capitalization of $34.4 billion, InvestingPro data shows argenx maintains a "GREAT" financial health score. Despite these results meeting expectations, argenx shares experienced a decline, closing down 8.6% against the XBI biotech index’s rise of 0.9%.

Leerink Partners attributed the pressure on argenx’s stock price to several factors, including investor disappointment over Vyvgart revenue results, which were affected by first-quarter seasonality headwinds. These headwinds included the reverification of benefits and the redesign of Medicare policies, leading to higher gross-to-net deductions. Additional concerns arose from uncertainties about the future net pricing of Vyvgart and limited key performance indicators regarding the commercial launch of a treatment for Chronic Inflammatory Demyelinating Polyneuropathy (CIDP). According to InvestingPro analysis, the stock currently trades at a P/E ratio of 32x, with additional valuation insights available in the Pro Research Report.

Despite these challenges, Leerink Partners expressed the view that the negative response to argenx’s stock was excessive and presented a buying opportunity. The firm highlighted argenx’s strong Vyvgart launch and anticipated multiple clinical data catalysts over the next 12 to 18 months. These catalysts are expected to reveal further value in the company’s pipeline for treating a variety of serious autoimmune conditions. InvestingPro data suggests the stock is currently undervalued based on its proprietary Fair Value model, with multiple additional ProTips available for subscribers.

argenx’s financial performance and commercial activities, as well as the potential in their pipeline programs, were key topics during the earnings call. The discussion aimed to provide clarity and address investor concerns regarding the company’s recent performance and future prospects in its various pipeline programs.

In other recent news, argenx SE has made significant strides with its product Vyvgart, impacting both its financial outlook and market presence. TD Cowen maintained its Buy rating with a price target of $761, highlighting strong market adoption of Vyvgart in treating chronic inflammatory demyelinating polyneuropathy (CIDP) and generalized myasthenia gravis (gMG), which is expected to boost the company’s earnings beyond Q1 estimates. Stifel analysts also reaffirmed a Buy rating with a $780 target following the FDA’s approval of Vyvgart Hytrulo, a pre-filled syringe for self-administration, which simplifies the treatment process for patients without the need for healthcare provider monitoring.

H.C. Wainwright echoed this sentiment, maintaining a Buy rating and a $720 target, emphasizing the ease of use of the prefilled syringe as a competitive advantage over treatments requiring professional administration. Guggenheim set a higher target of $1,100, citing the FDA approval as a reinforcement of argenx’s leading position in the anti-FcRn space. The approval allows for home administration, enhancing patient autonomy and impacting reimbursement under Medicare Part D.

Bernstein upgraded argenx from Underperform to Outperform, significantly raising the price target to EUR755, driven by improved commercial execution and promising phase 3 trial outcomes. The analysts have increased their earnings per share forecasts and introduced new elements into their financial models to reflect potential cash deployment in the 2030s. Overall, these developments underscore argenx’s strong market strategy and potential for growth, as reflected in the positive analyst ratings and increased price targets.

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