Repare Therapeutics anticipates key trial results by late 2025

CAMBRIDGE, Mass. & MONTREAL - Repare Therapeutics Inc . (NASDAQ:RPTX), a precision oncology company, has announced upcoming milestones for its clinical trials and a significant workforce reduction to extend its financial runway. The company is concentrating on three Phase 1 trials, with results expected in 2025.

The POLAR trial, testing the RP-3467 Polθ ATPase/helicase inhibitor, began in late 2024 and will provide initial data in Q3 2025. This trial includes patients with various advanced cancers and explores the combination of RP-3467 with olaparib, a PARP inhibitor.

In Q4 2025, initial findings from the LIONS trial, which evaluates the RP-1664 PLK4 inhibitor in patients with TRIM37-high solid tumors, are also anticipated. A Phase 1/2 expansion trial for pediatric neuroblastoma is set to commence in Q3 2025.

Additionally, the MYTHIC trial, assessing lunresertib in combination with Debio 0123, a WEE1 inhibitor, is slated for enrollment completion in Q2 2025. Repare reported positive data from the MYTHIC gynecologic expansion trial in December 2024 and is seeking partnerships for further development.

To align with these priorities, Repare has reduced its workforce by approximately 75%. The company reported having $152.8 million in cash, cash equivalents, and marketable securities as of December 31, 2024, which is projected to fund operations into late 2027. InvestingPro data shows the company maintains a strong current ratio of 6.45, with more cash than debt on its balance sheet, though it’s currently burning through cash at a significant rate.

Repare’s financial results for the fourth quarter and full year 2024 showed a net loss of $28.7 million, or $0.67 per share, for the quarter, and $84.7 million, or $2.00 per share, for the year. This compares to a net loss of $28.0 million, or $0.67 per share, for the same quarter in 2023, and $93.8 million, or $2.23 per share, for the full year.

The company’s strategic refocusing comes amid a challenging economic landscape but aims to advance its clinical programs efficiently. These developments are based on a press release statement and provide a snapshot of Repare’s ongoing efforts in precision oncology. InvestingPro subscribers can access 12 additional investment tips and comprehensive financial metrics to better evaluate Repare’s potential in the precision oncology space. Discover more detailed analysis and investment opportunities in the biotech sector with InvestingPro’s advanced tools and insights.

In other recent news, Repare Therapeutics has reported promising results from its MYTHIC Phase 1 clinical trial, which evaluated a combination therapy for endometrial cancer and platinum-resistant ovarian cancer. The trial showed an overall response rate of 25.9% in endometrial cancer and 37.5% in platinum-resistant ovarian cancer, with nearly 50% of patients experiencing progression-free survival at 24 weeks. Following these results, Repare plans to initiate a Phase 3 trial in the second half of 2025 and has received positive feedback from regulatory agencies in the U.S. and Europe.

Additionally, Stifel analysts have adjusted their outlook on Repare Therapeutics, reducing the price target to $3.00 while maintaining a Buy rating due to the company’s strategic shift towards early-stage assets like RP-1664 and RP-3467. Meanwhile, Bloom Burton & Co. downgraded Repare’s stock rating from Buy to Hold, citing the absence of human data for these early-stage drugs and removing the target price pending further results. These developments highlight the company’s transition from established projects to new, potentially value-creating assets.

Repare’s financial stability and forthcoming clinical readouts have influenced Stifel’s continued optimism, despite the risks associated with early-stage assets. Investors and analysts are closely monitoring the company’s progress, particularly with the planned trials and regulatory engagements, as these outcomes will be crucial in shaping Repare Therapeutics’ future prospects.

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