RFK Jr.’s potential HHS departure could benefit biotech stocks, RBC says

Published 10/09/2025, 15:06
©  Reuters

Investing.com - RBC Capital has released an analysis examining how Health and Human Services Secretary Robert F. Kennedy Jr.’s potential departure might impact the biotech sector amid growing criticism of his controversial vaccine positions. The biotech sector’s inherent volatility is evident in companies like Compass Pathways (NASDAQ:CMPS), which has seen a remarkable 46% gain over the past six months despite significant price fluctuations.

The investment firm notes that over 1,000 current and former HHS affiliates have signed a call for Kennedy’s resignation, medical and scientific groups have voiced opposition, and he faced bipartisan confrontation during a recent Senate Finance Committee hearing.

RBC suggests Kennedy’s departure would likely yield "mixed to positive readthroughs" for the biotech sector, potentially benefiting vaccine companies like Moderna (NASDAQ:MRNA), PrEP providers such as Gilead (NASDAQ:GILD), and neuropsychiatric drug developers including Axsome (NASDAQ:AXSM), Biohaven (NYSE:BHVN), and Alkermes (NASDAQ:ALKS).

The analysis points out that when Kennedy was initially nominated as HHS Secretary, the SPDR S&P Biotech ETF (NYSE:XBI) fell 8% over two days, reflecting investor concerns about potential sector disruption under his leadership.

RBC cautions that while Kennedy’s departure might improve overall healthcare investability by reducing unpredictability, any replacement would likely continue the administration’s agenda but with "less anti-vaccine stridency," and might potentially increase scrutiny on drug approvals and pricing.

In other recent news, Compass Pathways plc announced that its Phase 3 COMP005 trial for COMP360, a synthetic formulation of psilocybin, met its primary endpoint in patients with treatment-resistant depression. The trial showed a statistically significant reduction in depression symptoms compared to placebo, with a mean treatment difference of -3.6 points on the Montgomery-Åsberg Depression Rating Scale. Despite these results, Evercore ISI downgraded Compass Pathways’ stock rating to In Line from Outperform, citing concerns about the durability of the treatment effects. The firm reduced its price target to $6.00 from $11.00, highlighting questions about the long-term commercial success of the drug. Additionally, Compass Pathways held its Annual General Meeting, where all proposed resolutions were passed, including the re-election of several board members and the re-appointment of PricewaterhouseCoopers LLP as auditors. Safety data from the trial indicated no new or unexpected safety issues, aligning with previous studies. However, the modest clinical benefit reported in the trial led to a significant drop in the company’s stock value.

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