AngioDynamics at UBS Conference: MedTech Transformation Underway

On Monday, 10 November 2025, AngioDynamics (NASDAQ:ANGO) presented at the UBS Global Healthcare Conference 2025, detailing its strategic shift from a broad device portfolio to a focused MedTech company. The transformation aims to improve margins and drive growth, though challenges remain in market adoption and valuation alignment.

Key Takeaways

• AngioDynamics is transitioning to a MedTech-focused company, with 45% of revenue now from this segment.
• The company expects positive cash flow and improved gross margins by the end of the fiscal year.
• Significant growth is anticipated in the PE market with the AlphaVac system.
• No debt positions AngioDynamics well for continued investment in innovation and expansion.

Financial Results

• MedTech revenue grew over 20% in Q1, with a five-year CAGR of approximately 25%.
• The MedTech segment is projected to exceed 50% of total revenue in the next fiscal year.
• Achieved positive adjusted EBITDA last fiscal year, with positive cash flow expected this year.
• Corporate growth guidance is set at 5-7%, with Med Device growth expected between 1-3%.

Operational Updates

• AngioDynamics is narrowing its focus to three core MedTech areas: interventional oncology, arterial disease, and venous disease.
• Recent product launches include AlphaVac for PE treatment and expanded NanoKnife indications.
• The company achieved the number three market position in the PAD market with the Arion system.
• Distribution strategy shifted to hospitals, achieving a 60/40 split for Arion sales, aiming for a 50/50 balance.

Future Outlook

• AngioDynamics plans to enhance data generation and expand indications within its MedTech platforms.
• The Arion system is targeting coronary applications, potentially involving a four-year PMA process.
• NanoKnife is being explored for additional treatments, including stage III pancreatic cancer.
• The focus remains on organic growth, with external M&A unlikely in the next 3 to 5 years.

Q&A Highlights

• AngioDynamics sees significant potential in the PE market, focusing on mechanical thrombectomy.
• The company is aware of macroeconomic pressures but remains confident in its MedTech products.
• Hospital revenues for Arion now exceed 40%, with expectations to reach a 50/50 split with OBLs.
• The focus on early diagnosis and intervention aims to improve patient outcomes in prostate cancer.

For more detailed insights, readers are encouraged to refer to the full conference call transcript.

Full transcript - UBS Global Healthcare Conference 2025:

Danielle Intoffio, U.S. MedTech Analyst, UBS: All right, we’re good to go. Good morning, everyone. Thank you for joining us. I’m Danielle Intoffio. I’m a U.S. MedTech analyst here at UBS, and happy to kick off our annual healthcare conference with the AngioDynamics team, Jim Clemmer, President and CEO, Steve Trowbridge, Chief Financial Officer. Guys, thanks for joining.

Jim Clemmer, President and CEO, AngioDynamics: Good morning.

Danielle Intoffio, U.S. MedTech Analyst, UBS: Maybe just a quick start, quick intro to AngioDynamics, and we can launch into Q&A.

Jim Clemmer, President and CEO, AngioDynamics: Sure. Danielle, just the ground investors, AngioDynamics has a unique fiscal year. We begin each fiscal year on June 1. We’re about three weeks away from completing our second quarter, FY 2026. AngioDynamics is in a transformation. Investors who are new to this story would be interesting to learn. We’ve done a lot of work over the past five years to transform our portfolio and our company to a company that’s less kind of a device widget department store to a really focused MedTech company competing in large addressable markets, high gross margins, and areas that we can win, and we are winning. Danielle, we’d love to share that with you today.

Danielle Intoffio, U.S. MedTech Analyst, UBS: Great. Maybe, well, you promised me you would tell us how the quarter’s going. No, I’m kidding. Okay. Maybe let’s talk a little bit about the transformation, sort of what ending you guys are in at this point with the transformation and sort of what’s still to come.

Jim Clemmer, President and CEO, AngioDynamics: Yeah. So we started about five or six years ago. We really made the decision to change our portfolio. In 2019, we sold our largest business at the time, but it was a low-margin commodity business where we did not want to compete with really large players. That was important symbolically and realistically. We took a third of the proceeds from that sale that we received and later that year bought an Israeli-based startup with a really unique science to treat peripheral arterial disease. Today, that is our Arion system for PAD. We have gone from zero revenue in 2020 when we launched to this year we will do well over $60 million, organically growing it through a really great product in a market where we change outcomes in patients, and we can win competing with really good products. Danielle, that is symbolically part of our transformation.

As we sit here today, we’ve got two reportable segments. Our older, slower growth products is what we call our medical device portfolio. And those are great products. They’ll grow really kind of flat is what we’ve guided, flat growth. They provide us with EBITDA and cash to invest during this cycle. Our MedTech business is what we’ll spend more time with you on. That’s really where we think investors are excited to learn about our company. We’re in really good markets, and they’re growing fast, and we’re winning there.

Steve Trowbridge, Chief Financial Officer, AngioDynamics: Yeah. I think the point to understand is we’re probably in the sixth or seventh inning of the transformation. We’re not in the very early stages like we were a few years ago. As Jim mentioned, the MedTech business that we have has grown to a point where there’s critical mass in that business now. A few years ago when we started the transformation, less than 17% of our total revenue base was coming from the MedTech business. We’re now about 45% and ready to go over that majority of our revenue coming from MedTech. That’s driving gross margin. It’s getting us to a point where last fiscal year we were able to become EBITDA positive, adjusted EBITDA positive. We’re going to be adjusted EBITDA positive going forward.

For this fiscal year that ends May 31, we’re going to be cash flow positive in the business as well. Even though we’ve been doing some of those divestitures that Jim talked about, where you’re by definition going to be giving up some of your profitability and your cash generation for those low-growth businesses, we’ve now been able to grow the MedTech to a point where we’ve gotten over that transom.

Danielle Intoffio, U.S. MedTech Analyst, UBS: Right. That is a big key in MedTech. It is all about getting your weighted average, your WAMGER, up into the right. I guess I would ask, do you feel like you have the portfolio now in place in the MedTech business that will continue that trajectory? I guess in three years, what % do you think the MedTech business will be of sales?

Jim Clemmer, President and CEO, AngioDynamics: Yeah. To back into it, the MedTech business, we believe in next fiscal year will pass Med or Med Device. We think it’ll become our largest segment and continue going forward. It will be really critical. It is also higher gross margin, and it is providing us a nice P&L drop. As Steve said last year, they came adjusted EBITDA positive. That will only continue throughout our journey now. Investors will see a company with good top-line results, good growing gross margins as the mix is really important. Then bottom line, it will grow over time. We will have plenty of money to invest back into our business to fund more growth. Really, you will see a time with a really interesting P&L and a great balance sheet. We have no debt today, and we are going to generate cash this year and every year going forward.

Steve Trowbridge, Chief Financial Officer, AngioDynamics: On the growth question, the MedTech segment that we’ve had has grown quite a bit over the last three years. Over the last five years, we’ve had about a 25% CAGR for that MedTech segment. The thing that really excites us is that all of the businesses that we have in MedTech are platform technologies that we think with not too much additional effort, it’s mostly clinical and regulatory, can get us into new total addressable markets so that the growth can continue, not just the 25% that we’ve seen over the last five years. We’re excited about the opportunities for the growth for the businesses that they’re in now for the next three to five years. We’ve got opportunities in those platforms to use that same technology and continue that growth trajectory beyond the five-year period.

Danielle Intoffio, U.S. MedTech Analyst, UBS: Okay. Gotcha. Maybe let’s dig into the MedTech business and the total addressable market that you’re addressing or participating in there and what you see as the most critical growth drivers.

Jim Clemmer, President and CEO, AngioDynamics: Yeah. If you take a look at our MedTech portfolio, we have two cardiovascular areas we’re focused on and one interventional oncology area. I’ll back into it for a minute. The interventional oncology area is our NanoKnife product. We just got a label last December to treat intermediate-risk prostate patients. Really, really large market. We estimate over $2 billion globally, over $700 million in the U.S. of patients who are diagnosed with intermediate risk, we’ll call it, prostate cancer. About 40% of the men every year need a focal treatment option, which we give them now. We’re really excited to share more with you there. On our cardiovascular side, we compete on arterial and venous diseases. On the arterial side, we treat PAD with our NanoKnife, which gives you the Arion system. That’s about a $1 billion market in the U.S., larger globally.

Over time, part of our expansion going forward, we’re going to get into the coronary space, which is about double the potential size. We know our product is safe and effective and works really well. We want to get a label and treat there. Back to our venous side for VTE, many investors know how exciting this market is. We have our AlphaVac system, which was approved last year. We treat PE. We’re number three in a really large, fast-growing market. We’re going to take share from number one and two, but we’ll also expand the share as we’re all three working to grow the addressable market there as doctors get more comfortable using interventional devices to treat PE.

Danielle Intoffio, U.S. MedTech Analyst, UBS: Yeah. Yeah. I want to dig into that a little bit more. Maybe we can talk a little bit about how you see it. I do not think you guys have given sort of long-term guidance or any of that, but maybe you mentioned you are just ending the almost close to ending your second fiscal quarter. How you feel the year has started? I would love your just sort of high-level views on where you think healthcare is going. I am asking this question in the context of we have got the one big beautiful bill, and what is going to happen from a capital purchasing perspective, hospital budgets, things like that. Procedure volume trends have been healthy, but how you guys are thinking about since you are an off-cycle, and so you are guiding for a little bit of 2026, what is going to happen?

Jim Clemmer, President and CEO, AngioDynamics: I’ll give a quick note and then let Steve give detail. Macro-wise, we’re all watching the space. Our customers are under pressure. They’re trying to deal with Medicare and Medicaid changes, reimbursement. They’re under pressure. We get that. The good news for us is some of our products do have a capital and a disposable component. We’re not capital-intensive. We don’t rely upon that. We have alternative methods for folks to get our capital if they need it. We really want to sell the probes or the catheters that provide care and delivery of our technology. That’s a really, really good place to be today. There’s some uncertainty in the marketplace, as we know, but it’s not going to hold us back. We don’t believe it. Steve, on our Q1 and where we’re at today?

Steve Trowbridge, Chief Financial Officer, AngioDynamics: Yeah. Just on the macro point, being in healthcare, it’s great. It’s not complex at all, right? It’s very easy and simple and straightforward. As Jim said, there’s a lot going on there. In procedure volumes, reimbursement, pressure on the hospital system. The good thing is the markets that we are moving into with our MedTech business, we feel that they’re pretty well set up for the future. We’re still physician preference items. If you look at where reimbursement has been going in the areas, the trend has actually been okay in the markets we’re going into, particularly if you think about PAD, was pretty well pressured maybe three years ago. That seems to have kind of gotten through that. On the macro side, there’s absolutely going to continue to be challenges. We’re watching that to the point about the omnibus bill.

We’re keeping an eye on that. We think that there’s some opportunities maybe for some R&D credits that we’ll take advantage of, but nothing that’s derailing the overall strategy that we have. In terms of our first quarter, we were really pleased with the quarter that we announced that ended in August. We grew double digits. We had our MedTech business that was growing over 20%, seeing the right trajectory in terms of margins. We expect to continue to see a good trajectory for this year. We guided at the very beginning of the year. We raised guidance in terms of expectations for top line as well as the bottom line coming out of our Q1, which we tend to like to see a little bit more of the year going as we think about it. We’re pleased with the trajectory that we’re seeing at this point.

Danielle Intoffio, U.S. MedTech Analyst, UBS: Okay. Gotcha. Let’s actually talk about some of the key businesses here. You mentioned VTE, thrombus management. I mean, that’s a great market, very underpenetrated. Maybe you can talk about you grew 40% from your mechanical thrombectomy systems in Q1, I believe. Help us understand some of the drivers here of growth. Is it share gains? Is it market growth? A combination of both? How you’re helping? There’s been a building body of clinical evidence in this market and sort of what Angio is doing to contribute to that.

Jim Clemmer, President and CEO, AngioDynamics: Yeah. Entering this year at FY 2025, we had over a $40 million base in the space. We’re a legit player in the space. We’ve got an AlphaVac and an AngioVac product, each specifically designed for different reasons, but they’re really unique and special. AngioVac has been kind of our lead device for many years. It uses a centrifugal pump to help reinfuse the blood back in the body for very complex right heart cases and other things. A couple of years ago, doctors said, "Hey, we love the AngioVac. If you could take that off the pump, give us a purpose-built handle to control aspiration and power, we would love it." We compete really well with the burgeoning market to treat PE with interventional devices. We did that.

AlphaVac now, Danielle, does a really good job, gave the doctor the Vortex funnel tip that pulls more clot burden than anybody else into the device. A control mechanism that they do not have with other devices. We have seen really great growth. Number one, we are taking share in PE from the number one and number two players. We have the best product in the market, really well designed to treat PE in a safe and effective manner. Our apex data showed that in our study. We pull more clot out faster. Second, we are going to help the market grow. The other two companies are really, really good.

With us now entering here, you got three really good companies in this space, giving doctors confidence to stop using lytic-based therapies, which have been the historic treatment for PE, and really try an interventional device like one of our three to get the clot out of the body right away. Danielle, we’ll all three work together to grow that market, to do market development. We all believe the market’s about $3 billion potentially in the U.S. just to treat PE with these devices.

Danielle Intoffio, U.S. MedTech Analyst, UBS: Yeah. I mean, we’ve had a lot of clinical data over the last few weeks here, actually, on PE. Just curious about what you’re seeing, hearing in the real world as far as adoption of mechanical thrombectomy. It sounds like docs are pretty excited.

Jim Clemmer, President and CEO, AngioDynamics: Sure. I think that’s exactly right. I mean, we applaud Penumbra for the Storm PE trial. That was a landmark trial that was randomized. They were doing the right things. I mean, we think that that’s going to be a rising tide that’s going to lift all boats.

Danielle Intoffio, U.S. MedTech Analyst, UBS: A class effect more than that.

Jim Clemmer, President and CEO, AngioDynamics: Yeah. Absolutely. Because we firmly agree with the other competitors in the space that removing the clot is the most important thing that’s going to benefit the patients. We applaud the trial that they did. We’ve got our own data that came out with our PE trial. We’re going to be committed to also generate data in this space. We think it’s going to be important to continue to have that steady drumbeat of additional data supporting mechanical thrombectomy. Because as we sit now, your question, for the most part, we’re taking share, right? We know that this market’s growing, but given the size that we are and the timing that we came in, for the most part, the procedures that we’re getting today are share shift. We’re going to move into the blue ocean as well and try to do the market expansion.

As we sit here today, a lot of our growth has been mostly in that share shift. As Jim mentioned, we went from $30 million to $40 million last year in our overall mechanical thrombectomy business. We said we expect to go from $40 million to $50 million this year. Really good growth. We’ve got some tougher comps coming up in the back end, but we’re excited about the growth we’re seeing.

Danielle Intoffio, U.S. MedTech Analyst, UBS: Okay. Gotcha. What about from a pricing perspective? Are you guys at parity, and what are you seeing in this market from a price side of things?

Jim Clemmer, President and CEO, AngioDynamics: Yeah. We haven’t seen price move much in the last few years. They’ve just set their points and we fit right where they do. So we don’t think price is really a factor in this place. It’s really about care delivery and safety.

Danielle Intoffio, U.S. MedTech Analyst, UBS: Yeah. What do you think the barriers to adoption still are at this point? I mean, we’ve talked about per teams, for example, and it’s shocking that that’s not more widely implemented. I mean, how are you guys doing on the ground sort of helping hospitals build the infrastructure to really focus on mechanical thrombectomy?

Jim Clemmer, President and CEO, AngioDynamics: Yeah. It’s a great point. We believe in the per process, the theory, and how it works, how we can treat patients faster in a more safe manner. As more hospitals adopt the per process into their flow, we’ll be part of that process with our other peer competitors as well. It’s a really great way to give a patient a much more urgent need to treat a PE. We think using a mechanical product like ours or the others are the best way for a per team to do what it can do best. There’s really so much upside. I think investors have seen that, and they’re really bullish on how much upside exists in this space and how us three and maybe others will help solve that.

That per team approach has been a really, really great way to get customers used to treating people in a new way.

Danielle Intoffio, U.S. MedTech Analyst, UBS: Yeah. Totally.

Steve Trowbridge, Chief Financial Officer, AngioDynamics: Jim mentioned that we think we have the best products on the market. One of the things that we are doing to help aid that move is making sure that we have the features and benefits that we think are going to be important to physicians when they decide to choose mechanical thrombectomy for the first time. One of the things that is unique about AngioVac, as you mentioned, is that we have the simultaneous reinfusion circuit. That is for more complex cases, but when we set that up, there is zero blood loss, and they can have continuous aspiration for a time that you cannot do with any other product that is on the market. Our AlphaVac product, we would listen to the physicians, and we designed that product with them in mind. We added spherability.

We added the ability for them to go out and have the tactile feel to find out when they’re on the clot. We added some blood-limiting switches so they can decide between a 10 cc pull or a 30 cc pull. Let them use their skill as they decide to go after these disease states. We think continuing to innovate, listen to those physicians, make it easier to do these procedures is one of the ways that you’re going to continue to facilitate that change.

Danielle Intoffio, U.S. MedTech Analyst, UBS: Do you think the body of clinical evidence is there yet that this market should start to inflect, or do you think there’s still a ways to go? I’m just curious.

Jim Clemmer, President and CEO, AngioDynamics: Yeah. It’s funny. Asking myself and probably the other two companies on the stage, they said, "There’s enough evidence.

Danielle Intoffio, U.S. MedTech Analyst, UBS: Yeah. You know.

Jim Clemmer, President and CEO, AngioDynamics: If you ask a physician, they’ll say, "There’s never enough evidence.

Danielle Intoffio, U.S. MedTech Analyst, UBS: Sure.

Jim Clemmer, President and CEO, AngioDynamics: I think it’s a combination of both, Danielle. I think companies like us and what Penumbra did is really remarkable. We’re all going to invest in the space. We have a new trial we’re running now too. We’ll continue to show that these are safe and effective treatment tools, and the physicians will still expect more. That’s okay. We’ll meet in the middle there. I think there’s also a groundswell of people who’ve now used the devices and are gaining confidence in the patient outcomes and what they can expect. Really, lytics and drug therapy has been around so long, and it’s unpredictable, the outcomes. Nobody really loves it. I think the space is really going to burgeon and grow with a combination of data to support it and just use and just comfort and practice.

Steve Trowbridge, Chief Financial Officer, AngioDynamics: I think it’s the use case, right? Because I think the data is there that says off the bat, it’s safe, right? I think a lot of the trials that have been published are indicating that, yes, mechanical thrombectomy is a safe option. It’s when you use it, and if you’re in the room, and I’ve been in the room a couple of times, the patients get better immediately. On the table, they feel better when you go in, and you’re removing clots from their lungs. I think as more physicians get experience with that, they’re going to realize that this is the right answer as opposed to just getting systemic lytics and hoping that the clots will break out on their own.

Danielle Intoffio, U.S. MedTech Analyst, UBS: Yeah. Okay. Agree with all of that. Maybe let’s talk about Arion. Solid 20% growth exiting Q1. Can you maybe talk a little bit about where Arion stacks up versus other atherectomy modalities? How has specifically BTK penetration trended as you scale randomized and registry evidence there?

Jim Clemmer, President and CEO, AngioDynamics: Yeah. We’re really excited with the Arion product. This is the product I mentioned that we acquired in 2019. We launched it in September of 2020. Six months into the pandemic, not a great time to launch a new product as hospitals are telling us, "Hey, don’t come in with either product today." We focused on the OBL market first, which treats a lot of the PAD treatments here in the U.S. We gained a lot of share initially. We have a laser-based product the way it works. Laser energy is directed through our catheter to break up soft or hard calcium or plaque clogging up the arterial veins. Our product’s better than the other laser because it can do above and below the knee, which was the other product didn’t deliver there. We can break up the hard calcification and plaque below the knee.

That’s what we’re measuring now with our New Ambition study. We’ve taken share from the other five companies in the space. They’re really big companies. We all know who they are. We’re a small company. We can’t bundle or tie it to other things in the lab, but our product is that much better. We’ve taken a lot of share. Today, we’ve gone from the sixth entrant to number three in the market.

Danielle Intoffio, U.S. MedTech Analyst, UBS: Oh, wow. Okay.

Jim Clemmer, President and CEO, AngioDynamics: We’re growing, taking share every year. The market isn’t growing at the rate we are. We’re number three out of six really good companies in the space in PAD. Continue to grow double digits for years to come. What we’re also excited about, Arion’s a platform. The way we deliver energy through the device, we think it can do other things. Our European customers now that we have a CE mark are really excited about it as a coronary product. They’ve done some work overseas to double-check that it’s safe and effective. We believe it is. We’ve talked to our investors. We’re going to look to get on label here in the U.S. It’s probably going to be a four-year PMA, but we’ll give you more detail when we have it. We’re really excited about what that market can do.

We’ve also seen from customers who’ve used it, "Hey, guys, this breaks up the medial calcification, kind of like Shockwave. There’s a shockwave effect." We said, "Great." The customers are leading us to new areas where we can really look at how we can penetrate larger addressable markets with the same science and technology. Danielle, we’ll grow Arion for years to come, not just in the OBLs. We’ve shifted our focus to the hospitals in the last couple of years, and a lot of growth is coming from there. Above and below the knee, instant restenosis, OBL hospital, coronary peripheral, we really love this device.

Danielle Intoffio, U.S. MedTech Analyst, UBS: Okay. What is the mix right now of Arion revenue in the OBL versus hospital?

Jim Clemmer, President and CEO, AngioDynamics: Hospital is now over 40%. It is coming up to near the OBL mix. It will probably pass it soon. It will stay around 50/50 over time. It is really important for us. It is a higher ASP. It is a more stable customer that we would love to get. We want to get it in that cath lab, have it used for more devices.

Danielle Intoffio, U.S. MedTech Analyst, UBS: Yeah. Sure.

Steve Trowbridge, Chief Financial Officer, AngioDynamics: This has been a big switch for us. As Jim mentioned, we launched the product right in the middle of COVID. Hospitals were saying that they were just building up capacity to treat COVID patients, but the OBLs were open. When we were doing our due diligence on this technology, it was about a 60/40 split hospital to OBL. That flipped when we got to COVID, and it went to probably 60/40 OBL versus hospital. Originally, when we launched our product, we were probably over 90% in the OBL because that’s where the customers were. That’s where we were looking to grow. Over the last two years, our team has done a great job having this initiative to get more into the hospitals to get us to where we are at that 60/40 split, OBL versus hospital.

A lot of times we get asked, "Where do you want to end up?" 50/50 is probably a good goal. I don’t think we’ll get to a point where it’s more than that. I think we still have some runway to grow within the hospital, but we’re also growing in the OBLs as well. We are going to continue to open up new customers in the OBL setting. We are going to continue to open up customers in the hospital setting, getting ready for the future with coronary.

Danielle Intoffio, U.S. MedTech Analyst, UBS: Coronary.

Steve Trowbridge, Chief Financial Officer, AngioDynamics: We think we’ve got a good runway to continue to take share.

Danielle Intoffio, U.S. MedTech Analyst, UBS: Pricing in this market, so you mentioned there are five very big competitors here, right? And reimbursement has been volatile over the last few years in this market. How durable do you think pricing is here? Is this a market where you do think you’re going to have a little bit more pricing pressure?

Jim Clemmer, President and CEO, AngioDynamics: Yeah. When we did our thesis to enter the market, we expected pricing to come down. It did, along with our expectations. Recently, we’ve seen some kind of bottom.

Danielle Intoffio, U.S. MedTech Analyst, UBS: Stabilization.

Jim Clemmer, President and CEO, AngioDynamics: Yeah. If anything, even next year, some of the work we’ve seen will help OBLs. There’s some new pricing models, some Medicare reimbursement that we think is slightly favorable. We don’t think it’s going to be a headwind as it has been. If anything, maybe a slight tailwind. Either way, we’re going to take share. We’re at a place where we’re pleased with our ASPs, our margins, and where the competitive pricing is. We think we’re in a pretty good spot. If it gets a little better, like it looks like it might, then terrific.

Steve Trowbridge, Chief Financial Officer, AngioDynamics: You talked about the data in the mechanical thrombectomy space. We think data is just as important here in the PAD space, which is why we’re running the Ambition BTK study. To your question about stabilizing the market, we think that that study is actually going to be pretty important to show that balloon angioplasty with atherectomy is just as safe and potentially even more effective than just balloon angioplasty alone, particularly below the knee. As Jim mentioned, this is the first laser product that can work below the knee. We’re excited about doing that. Since we’ve launched this product, just about 50% of our cases have actually been below the knee. We’ve had about 10% in in-stent restenosis, and then the other half has been evenly split in half between above and below the knee.

We know our product works. Continue to provide that data foundation to show that atherectomy is a good choice, is a safe choice, and is really effective for these patients. We want to make sure that we limit the amount of amputations that are going forward.

Danielle Intoffio, U.S. MedTech Analyst, UBS: Which is, it’s wild how many amputations are still done.

Steve Trowbridge, Chief Financial Officer, AngioDynamics: We do not think they have to happen, all of them.

Danielle Intoffio, U.S. MedTech Analyst, UBS: Right. Right. I wanted to ask as well, what do you think at this point the below-the-knee intervention market is growing? One of the issues, not issues, I guess, but five to ten years ago, lack of clinical evidence, right? There is a little bit of the wild, wild west.

Steve Trowbridge, Chief Financial Officer, AngioDynamics: Yeah. There was.

Danielle Intoffio, U.S. MedTech Analyst, UBS: How do you think it’s evolved? Are we there yet where this can really be the standard of care?

Jim Clemmer, President and CEO, AngioDynamics: Yeah. We believe it can be. About a month ago, we sponsored a cardiovascular scientific forum, and one of our keynote speakers stood up on the podium and told her colleagues, "150,000 patients are going to have an amputation this year in the U.S. That’s unacceptable. There are ways to treat these patients better than doing that, guys." Her point is really valid. We know Arion is the best and safest way the way it works. Sponsoring the Ambition BTK study, we believe, shows our faith in what we can do in a randomized control trial. We think it’ll give the outcomes that then physicians can trust, and we can reduce those patients getting amputations and then gain traction in the space.

Steve Trowbridge, Chief Financial Officer, AngioDynamics: Yeah. We firmly believe in our product. We firmly believe in this treatment. We still think there’s probably a little bit more data that’s necessary. That’s why we’re doing Ambition and the Ambition BTK study. I don’t know that we’re quite there yet, but we think we will. We think we can get there.

Danielle Intoffio, U.S. MedTech Analyst, UBS: Are the majority of these doctors doing these procedures still vascular surgeons or interventional cardiologists as well?

Jim Clemmer, President and CEO, AngioDynamics: For Arion, it’s mostly vascular surgeons. You have more there. You have some mix of treatment, but vascular surgeons primarily is the main treatment.

Danielle Intoffio, U.S. MedTech Analyst, UBS: Okay. So it’s still the same call point that’s doing the amputations as well.

Jim Clemmer, President and CEO, AngioDynamics: Yeah.

Danielle Intoffio, U.S. MedTech Analyst, UBS: Is it just a matter of getting these patients diagnosed earlier? You think earlier intervention, like stop the progression, don’t let them get to the point of critical limb ischemia?

Jim Clemmer, President and CEO, AngioDynamics: Exactly.

Steve Trowbridge, Chief Financial Officer, AngioDynamics: I think there’s part of that. I mean, early diagnosis is going to help in almost any setting that you can think of, right? Particularly when we talk about the prostate market, that’s another area where we think that early diagnosis would be helpful, as we have with NanoKnife in pancreas too. When you think about PAD, yes, early diagnosis, but then also awareness of the treatment, right? I think the difference between the mechanical type rotational devices that were really working below the knee historically and then laser above the knee, you understand that sometimes you’ve got to go in and open up that vessel, but those rotational devices, they have some safety concerns for some legitimate safety concerns, which is why we think the Arion technology is such a good option.

The safety profile of laser, it uses a wavelength that’s very different than the laser that had been on the market before. It’s actually absorbed by the vessel walls. So the safety profile is fantastic. You look at the IVE that we had, zero dissections. And then the way that the energy is delivered to be able to break up that hard calcification, which is usually what you see below the knee, the versatility that Jim talked about with Arion, we think makes it a perfect solution. That’s why we think we’re going to continue to keep the ball rolling.

Danielle Intoffio, U.S. MedTech Analyst, UBS: Yeah. Yep. Okay. I want to make sure we touch on NanoKnife here. Maybe some of the momentum in prostate following the FDA clearance in 2024. You’re now a year into this, and how market adoption has progressed. Maybe let’s start there.

Jim Clemmer, President and CEO, AngioDynamics: Yeah. So we’re really excited in what we’ve received. We knew that NanoKnife, which is a non-thermal ablation tool, uses energy, electricity, actually, to break down the cell wall in the diseased tumor and let the body flush the cancer out and die naturally in the body. It’s a unique product. We got on label last December. A preserved study showed it’s safe and effective, showed really good outcomes in the men who need to be treated. We’re talking about Gleason 7 intermediate risk patients. Today, we’re kind of focusing on that intermediate market. Maybe we can do more above and below that, but today, that’s over 40% of the men being diagnosed. It’s a really large market today. We’re excited by the way it treats and how it works. We’ve seen really good feedback.

For the first time, we can actually talk about it, educate men and the urology community about the device, create awareness for the men who are diagnosed. Every day, tonight, 500 men will go home and tell their family, "I just got diagnosed with intermediate risk prostate cancer." What does that mean? Now they’ll go home and Google it or go on Facebook. They’ll learn about our product, which they couldn’t have done a year ago. We’re getting a lot of inbound interest. You’ve also got urologists that always believe men needed a good focal treatment option. Too many men were getting radical prostatectomies that didn’t need it and didn’t need to have those side effects. Today, the urology community, the awareness with men are really leading to really great growth. You’ve seen that in our numbers. Q1 was terrific. Even last year was.

What’s important for us, January 1, our CPT1 code kicked in. Our team did a really good job. We got on label and got our CPT1 code approved both last year. We’re really excited by what this will do to open up more avenues for us.

Steve Trowbridge, Chief Financial Officer, AngioDynamics: Jim talked about the options that we think are important to give to men. We’ve seen a tremendous amount of interest from the urology community in the NanoKnife procedure because we think that they believe the way that we do that men have been given the wrong choice up to this point. When they’re diagnosed with prostate cancer, at this point, they’ve had one of two choices on the polls: either do nothing, so have active surveillance or watchful waiting, or have a radical prostatectomy. Overall survival has been good in terms of treating prostate cancer, but then they’ve had to deal with side effects. A tremendously large percentage of men who have a radical are going to end up with really debilitating quality of life side effects in terms of impotence or incontinence. That’s where we think NanoKnife can play a role.

Jim mentioned we can destroy the tissue cells, but what’s really unique about NanoKnife is that critical structures that are in the ablation zone, blood vessels, bile ducts, nerve endings, aren’t impacted, and they remain patent. That allows us to do that treatment for those intermediate risk patients who are right on the cusp of saying, "Do we either do nothing or go to a really invasive procedure where you’re probably going to end up with debilitating side effects?" Now you can get treated. We can destroy the tissue. We can destroy the cancer cells, but preserve that quality of life.

Danielle Intoffio, U.S. MedTech Analyst, UBS: Yeah. So is this almost like you’re really growing the intervention market here versus really competing? Because it sounds like it’s all about earlier intervention?

Steve Trowbridge, Chief Financial Officer, AngioDynamics: Yeah. It’s a great point. If you think about some of the other technologies that we talked about, each of our growth drivers is in a different stage of its life cycle, right? We talked about Arion. Bit more of a mature market. That’s a share shift, right? That market isn’t growing much, but we think we’ve got the technology that can continue the share shift that we’ve seen. Mechanical thrombectomy, it’s pretty well understood, but it’s a growing market. Really, the story there is to continue to turn the surge market into the total addressable market, the total addressable market into the surge market, excuse me, in mechanical thrombectomy. NanoKnife is a little different. We’re doing a little bit more market development there, right? Because there’s a unique technology.

There’s a unique way of thinking about delivering this therapy now that we’re going to have to continue to educate the market on.

Danielle Intoffio, U.S. MedTech Analyst, UBS: Okay. Last question on NanoKnife. As far as innovation in this market, you talked about all your products as platforms. I mean, what would innovation look like here?

Jim Clemmer, President and CEO, AngioDynamics: We believe NanoKnife also could be safely used to treat other difficult tumors. We’ve done a study called DIRECT that we’ll launch soon to data for people with stage III pancreatic cancer, a really, really difficult treatment option. We think Nano is a safe and effective way to give them a new hope. What we’ve learned through the PRESERVE study, now following patients afterwards, doctors who’ve treated men with intermediate risk prostate are now telling us, "Hey, guys, there’s a BPH effect you have here. NanoKnife treatment seems to shrink the prostate, and men are now flowing better." There’s a really large market. The BPH market, as we all know, is much larger than just the prostate market. We’re watching that very carefully, very closely, but we believe we have a really unique way to treat men with BPH in a different way.

Danielle, it’s almost symbolic of our company as a whole. Each of the three platforms we just talked about has a lot of room to grow. We’re going to focus our energy and our efforts on investing into these three platforms and opening up more TAMs and larger markets throughout the science that we have today.

Steve Trowbridge, Chief Financial Officer, AngioDynamics: I think that’s going to be the key for innovation for Angio going forward, right? Innovation and growing your markets and thinking about future growth is what’s imperative if you’re going to have a really well-performing stock in med tech these days. Where I think we’re uniquely set up is for us, the innovation is really data generation and increasing our opportunity to get into those markets with the existing technology.

Danielle Intoffio, U.S. MedTech Analyst, UBS: Right. Leveraging the existing platform technology.

Steve Trowbridge, Chief Financial Officer, AngioDynamics: We don’t have a lot of R&D that’s necessary to take Arion into the coronary, right? There isn’t a lot of R&D that’s going to be necessary to take our AngioVac product from being focused on the right-sided interventions to potentially going into the left side of the heart where there’s a huge unmet need. With NanoKnife, we don’t have to change the product, but we just have to continue to get the data and increase awareness and make those changes in areas like prostate, potentially with BPH, and then other solid tumors as well.

Danielle Intoffio, U.S. MedTech Analyst, UBS: I got you. We did not really talk about the med devices business, but maybe let’s touch on that a little bit. You mentioned basically flat-ish growth there. Sort of walk us through what’s going on there. Will that ever return to growth? Or how do you look at the sort of midterm outlook for that business?

Jim Clemmer, President and CEO, AngioDynamics: Yeah. So we’re not investing in the space. We’ve got a few really good products there in good markets, but it’s a spot that we’ve decided we’re not going to invest resources and compete heavily for share gains there. It’s doing its job for us. We’re serving the market with really good products there, but it’s also giving us a means to an end. We’ve used the cash and the capital it’s thrown off to invest in these really interesting markets we talked about. Over time, it’s gone from 85% of our revenue now to a little over 50%. It’ll soon be past. It gets less important to us. Today, it helps us get EBITDA and cash that we can use and stabilize our company. Over time, the med tech business is the growth engine for our company. We think most investors are looking there.

Steve Trowbridge, Chief Financial Officer, AngioDynamics: Yeah. We tell people to think of that overall segment as about a 1-3% grower and kind of in the short to medium term. It is not going to go backwards. As Jim said, we are not going to invest a lot in it. We are going to get that kind of very low single-digit growth. It is lower gross margin, but it definitely provides a ton of EBITDA and a ton of cash generation, which has facilitated this transition that we talked about at the very beginning.

Danielle Intoffio, U.S. MedTech Analyst, UBS: Steve, I wanted to ask you or Jim as well. You did talk about the very healthy balance sheet, no debt. Maybe talk a little bit about capital allocation and how you’re thinking about that over the next few years.

Steve Trowbridge, Chief Financial Officer, AngioDynamics: Sure. Yeah. I think we hit on it. It’s going to be investing in the innovation related to the med tech business. Right now, we think we’ve got a ton of opportunities in each of those growth drivers that we have in med tech. That’s where our focus is going to be. We get the question a lot, "What about external M&A? Do you want to add more growth drivers to your business?" At some point, probably, but not in the next three to five years, I would say.

Danielle Intoffio, U.S. MedTech Analyst, UBS: Sounds like you don’t need to.

Steve Trowbridge, Chief Financial Officer, AngioDynamics: I don’t think we need to. I don’t think we want to add more complexity. We’re still a small company. We’re still a little hard to understand. We want to continue to refine our story. We want to focus on the growth areas. We’ve got the opportunity, as we said, to invest in data and indication expansion. M&A is always hard, right? It’s always a crapshoot. R&D is tough. The only thing that has less of a hit rate is external M&A. We think we can focus on what we’ve got right now.

Danielle Intoffio, U.S. MedTech Analyst, UBS: Yeah. That makes sense to me. Okay. Maybe let’s touch more specifically on the fiscal 2026 guide and the mid to 5-7% sales growth. Can you talk about some of the puts and takes? We only have a minute here, but maybe wrap us up in sort of what are the puts and takes to the guide? I always like to ask this question, where do you think there’s a disconnect from an investor perception perspective versus what you think, AngioDynamics?

Steve Trowbridge, Chief Financial Officer, AngioDynamics: Yeah. That would probably take us 35 minutes to talk about because we think that there is.

Danielle Intoffio, U.S. MedTech Analyst, UBS: Okay. I started with that.

Steve Trowbridge, Chief Financial Officer, AngioDynamics: We think that there is a big disconnect in terms of the valuation we’re seeing in the market today and the value that our assets have and the way that we’ve been running the business. That’s okay. We’re going to continue to execute. I think it really goes to what you said is hitting the numbers that we put out there. Putting out the growth, you said 5-7%. That’s at an overall corporate perspective, but we think it’s important to look kind of the level down, see the growth that we expect, the double-digit growth we expect to see in the med tech segment. Then we’ve guided flat, and we’ve said assume 1-3% kind of in the long term as a growth in the med device.

We’re pretty confident in setting it up that way and then seeing gross margin expansion coming from this revenue shift as the med tech business grows and then seeing that drop down to being positive adjusted EBITDA and then getting to positive cash flow this year.

Danielle Intoffio, U.S. MedTech Analyst, UBS: Yeah. Sorry I didn’t give more time for that question because I think it’s an important one. There’s a lot of disconnects out there.

Steve Trowbridge, Chief Financial Officer, AngioDynamics: Yeah. We agree.

Danielle Intoffio, U.S. MedTech Analyst, UBS: Listen, guys, thanks so much for being here. Really appreciate it. Honored to kick off with you guys. Thank you.

Steve Trowbridge, Chief Financial Officer, AngioDynamics: Thank you for having us.

Jim Clemmer, President and CEO, AngioDynamics: Thank you. Appreciate it. Thank you.

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