Charles River at Jefferies Conference: Strategic Moves Amid Challenges

On Wednesday, 04 June 2025, Charles River Laboratories (NYSE:CRL) presented at the Jefferies Global Healthcare Conference 2025. The company shared a cautiously optimistic outlook, highlighting both achievements and challenges. Notable was the 1.8% revenue decline, countered by improved operating margins and earnings per share growth. A strategic review with Elliott Management is underway to enhance shareholder value.

Key Takeaways

• Charles River reported a 1.8% decline in Q1 revenue but saw a 60 basis point improvement in operating margins and a 3% increase in EPS.
• The company is undergoing a strategic review with Elliott Management, exploring M&A and potential divestitures to enhance shareholder value.
• A cost savings program aims to reduce the cost structure by 5%, with expected savings of $175 million this year.
• The manufacturing segment targets 30% margins by year-end, driven by Biologics Testing and Microbial Solutions.
• Charles River emphasizes its commitment to reducing animal use, with $200 million in revenue from Non-Animal Methods (NAMS).

Financial Results

• Q1 2024 Performance:

- Revenue decreased by 1.8% year-over-year, surpassing previous expectations.

- Operating income margin improved by 60 basis points.

- EPS increased by 3%.

- Achieved a net book-to-bill ratio above one for the first time in two years.

• Cost Savings Program:

- Targeting a 5% reduction in the cost structure.

- Anticipated savings of $175 million this year and $225 million next year.

• Guidance:

- EPS guidance raised by $0.20 to a range of $9.30-$9.80.

- Revenue growth guidance improved by 1% to a range of -4.5% to -2.5%.

Operational Updates

• Site Consolidation:

- Plans to reduce the site footprint by approximately 20 sites while maintaining client services.

• Staffing Reduction:

- Achieving $75 million in sustainable savings through headcount reduction and process optimization.

• Manufacturing Solutions:

- Aiming for near 30% margins in the manufacturing segment by year-end, focusing on Biologics Testing and Microbial Solutions.

Future Outlook

• Manufacturing Segment:

- Targeting improved margins, with Biologics Testing expected to perform better in upcoming quarters.

• CDMO Business:

- Not expected to return to profitability this year but has a path to future profitability.

• DSA Segment:

- Optimistic about early positive pharma bookings despite a current decline in pharma revenue.

• Biotech and RMS Segments:

- Biotech shows two quarters of revenue growth; RMS expects limited impact from potential changes in NIH funding.

Q&A Highlights

• Cost Structure Changes:

- Implemented site and staffing reductions to mitigate margin impacts.

• Manufacturing Services:

- Two of three manufacturing service parts are operating near target margins.

• Strategic Fit:

- The review focuses on strategic alignment and potential divestitures.

• NAMS Transition:

- The FDA announcement is seen as an evolution of efforts to reduce animal use, with significant revenue already from NAMS.

• RMS Exposure:

- Minimal exposure to government and academic spending, with limited impact expected from budget cuts.

Readers are encouraged to refer to the full transcript for a more detailed account of the conference call.

Full transcript - Jefferies Global Healthcare Conference 2025:

Dave Windley, Analyst, Jefferies Healthcare Equity Research: Hi. Good morning. I’m Dave Windley with, Jefferies Healthcare Equity Research. Welcome to Jefferies twenty twenty five New York Conference. Pleased to have you here.

Appreciate the support. See some, familiar faces in the crowd here in person, and certainly welcome to the folks that are listening to the website live or on demand. So thank you again. Our next company to present or to talk to us in fireside style is Charles River Laboratories. I’ve covered the company for quite a long time.

Burgitt, I’ll admit I was just looking at your LinkedIn profile and comparing our tenures. And and at first, I I so I’ve been at Jefferies coming up on twenty five years, and I saw twenty three years at Charles River. And then I scrolled down a little more and saw across two stints, it’s it’s even longer than that. So congratulations on your long tenure with Charles River. Burgett Gershuk is the EVP and Chief Operating Officer of the company.

Todd Spencer is also here with us in the crowd. I’m going to turn it over to Burgett to talk a little bit here to lead off, and then we’ll get into questions. Thanks again.

Burgett Gershuk, EVP and Chief Operating Officer, Charles River Laboratories: Thanks, Dave. Thanks for having us today. And yes, I have thirty three years, so I have a few years

Dave Windley, Analyst, Jefferies Healthcare Equity Research: on the I wasn’t going say the number, yes.

Burgett Gershuk, EVP and Chief Operating Officer, Charles River Laboratories: And thirty three proud years at Charles River. So but let me start the session today with just a little update on our Q1, which we felt was a solid performance. It was better than we had expected and prior outlook. We ended up with still a revenue decline, but less than expected at minus 1.8. We were it was great to see that we achieved a OI margin improvement of 60 basis points and an EPS growth of 3%.

The this was a clear result of our cost savings actions and cost savings program that we have initiated just about eighteen months ago now and where we are have reduced our cost structure by roughly 5%. Also great to see that we have for the first time in two years achieved a net book to bill of above one, which we’re waiting for quite a while. This was primarily driven by strong bookings particularly in our Pharma segment, but also by moderating cancellation rates in all our client segments. So really good to see and gives us some confidence going forward. This allowed us to improve our guidance for EPS by €0.20 to €9.3 to €9.8 and also our revenue growth to by 1% to minus 4.5 to minus 2.5%.

And my colleague Flavia Pease reaffirmed that earlier this week. So I’m happy to see we are seeing some stability there. We also talked about the FDA announcement at our earnings call. And that’s something that we will probably touch on later in the questions. So I will leave that to that.

Dave Windley, Analyst, Jefferies Healthcare Equity Research: Excellent. Okay, great. Thank you for that. Tee up, I think a good place to start is to key on the cost structure changes that the company has made. So I guess I’d start with compliments on once management identified that the environment was truly weakening, you acted pretty quickly in addressing and rightsizing cost structure and figuring out ways to mitigate margin impact.

So in that regard, maybe you could talk to a few of the areas or the most significant areas where you’ve pulled levers. But then I want to take us into the strategic review and what more could be done. So I’ll let you talk about what you’ve done so far first.

Burgett Gershuk, EVP and Chief Operating Officer, Charles River Laboratories: Yes, certainly happy to. So as I said, we reduced our cost structure by roughly five percent. And there are some key areas that we are executing on. Some of that cost reduction is completed. Some of that is still in progress.

It will translate to roughly $175,000,000 of cost saving this year and then $225,000,000 forecasted for next year. So it will have a lasting impact. Some of the areas that we have looked into or executing on is for example site consolidation. So between the sites that we have consolidated or eliminated over the last year and the ones that are still in progress, we will reduce our footprint by about 20 sites. Many of those are quite small and we will maintain the services and solutions for our clients in one of our bigger sites.

So we are not reducing our services footprint, but we are reducing our square footage overall and actually makes us a stronger company and a more competitive company because our customers are actually able to do the same amount of work or the same work in all under one roof. So it’s actually something that’s very, very positively seen. Other areas that we have looked at is obviously are executing on is the reduction of staffing. Some of that will return as volume growth returns, particularly in areas where we used attrition to allow the staffing numbers to go down. But we also have roughly $75,000,000 of sustainable savings where we reduced headcount and other costs that we don’t think we need to rehire.

So we made process changes, automation, some outsourcing and other areas. I’ll leave it with that. I could go on for half an hour on that. But there’s a lot of activities going on.

Dave Windley, Analyst, Jefferies Healthcare Equity Research: Got it. And for clarification on the site consolidation, are the preponderance, excuse me, of those breeding facilities, barrier room type facilities? Or is it other areas of the business?

Burgett Gershuk, EVP and Chief Operating Officer, Charles River Laboratories: So we have looked at our holistic portfolio at all our sites that are in the Charles River network. And it actually impacts sites in all our businesses. A lot of those are the majority of those are in DSA and in RMS. There’s some Cradle facilities part of that as well. There’s actually seven to eight facilities in Cradle that we have reduced.

And but every business has had some sites that were consolidated.

Dave Windley, Analyst, Jefferies Healthcare Equity Research: Okay. So then, kind of rolling forward to the strategic review. So announced the agreement, the collaboration with Elliott Management. And, some of the emphasis, I guess, in discussions with you, with management have been around the preexistence of your special, sorry, strategic planning, capital allocation committee. And so I suppose the question then is, as I said before, you’ve been pretty proactive about this.

What remains? Or what more can be stimulated by shining a brighter light on this?

Burgett Gershuk, EVP and Chief Operating Officer, Charles River Laboratories: Yes. I’m happy to talk about that, obviously. So yes, in our earnings calls, we announced that we will undergo a strategic review. And this strategic review is we actually do that every year, but we have some new Board members. And with the kind of fresh perspective, we want to do a very comprehensive review and to see where we possibly can improve shareholder value in the company.

So what we will do there, we will look at every business. We’ll see what fits, what doesn’t fit. Are there any other costs out that we can do? Certainly part of it. But I believe it’s very much about the strategic fit and where we can maintain synergies.

At this point, we are in very, very early stages. And so we’re going to look at all possible solutions including if there’s M and A that actually would improve our shareholder value, but also areas that we shouldn’t play in. Once we go through that, we will be for sure a few months. So we’ll be a little bit of time before we can report out on that. We’ll certainly come back and provide more information.

Dave Windley, Analyst, Jefferies Healthcare Equity Research: So on that, I think the question was asked on the call and I get the question, do you do I think do people think that you’ll have an update, on the 2Q call? What you just said suggests that’s probably a little too early. Do you think that’s fair?

Burgett Gershuk, EVP and Chief Operating Officer, Charles River Laboratories: That’s fair. It will definitely not be on the Q2 call. We’re just starting the process. This will take some time. And as I said, we’ll do a comprehensive analysis, some of the parts and everything else included, that will take some time.

Dave Windley, Analyst, Jefferies Healthcare Equity Research: Yes. And when you think about the businesses, you mentioned very much an emphasis on strategic fit. It seems like, you know, DSA is the biggest business. RMS is probably the most germane then of the other two segments to your core DSA business. I’m inclined to ask how how to divest of of parts of the portfolio is the company, is management?

And could that be up to and including a full segment of the business?

Burgett Gershuk, EVP and Chief Operating Officer, Charles River Laboratories: Yes. I think it’s just a little bit too early to speculate. Let us go through the review. We strongly feel that our stock price is extremely undervalued right now and particularly since the FDA announcement. So we are going to look at all options and anything that is reasonable and makes sense, we will entertain.

But we’re really early on. And so it’s just too early to speculate. Okay. Got

Dave Windley, Analyst, Jefferies Healthcare Equity Research: it. So digging into segments a little bit, the manufacturing services or manufacturing solutions business kind of has three big parts. I think management Flavia has described that two of those are operating at or pretty close to target margins, one a little more lagging. The two that are performing better microbial and biologics testing. Where would how would you describe their performance versus where you think they can achieve or what are target margins?

Burgett Gershuk, EVP and Chief Operating Officer, Charles River Laboratories: Yes. So where we believe and to get to later in the year is actually that we are getting closer to 30% margins for our Manufacturing segment. And this is primarily driven by the two segments Biologics Testing and Microbial Solutions. Biologics Testing had a little bit of a soft quarter, which we see regularly because of seasonality. A lot of the manufacturing sites that we are supporting may that be pharma or CDMOs or biotech are actually closing down over the holiday periods and then we don’t get samples in early January.

We believe this business will return to better performance and growth in the following quarters. And with that, our margin will improve. And then our microbial business, we have said before this is a highly profitable business. And we are continuing to see solid growth there and that will be always a contributor to that. So as I said, we believe that, that business as a Manufacturing Solutions as a whole can definitely go come back to just about 30% for the year.

Right.

Dave Windley, Analyst, Jefferies Healthcare Equity Research: And is that that’s 30% for the year or by the end of the year?

Burgett Gershuk, EVP and Chief Operating Officer, Charles River Laboratories: By the end of the year. Yeah.

Dave Windley, Analyst, Jefferies Healthcare Equity Research: And so the path to that, I think, clearly, biologics testing was probably a little lower because of the slow start volumes. But the path to that 30% is does an improvement in, I’ll say, in air quotes, normal on biologics testing get you there? Or does the CDMO part of manufacturing need to improve from its current levels?

Burgett Gershuk, EVP and Chief Operating Officer, Charles River Laboratories: It’s primarily driven by the biologics testing. So our CDMO business this year is impacted by actually two commercial clients. And one of them will discontinue the work with us because of consolidation of their suppliers. And the other one has a little bit of a delay in their program. And so the CDMO business will most likely not return to profitability this year, whereas we have made a lot of improvements and have a road to profitability going into the future and believe that we can build this as a strong really strong business, Sam.

Dave Windley, Analyst, Jefferies Healthcare Equity Research: On that last part, is that road on existing client base or I’ll say and or development stage activities? Or does the road to profitability in the CDMO need some commercial larger scale commercial volume?

Burgett Gershuk, EVP and Chief Operating Officer, Charles River Laboratories: Yes. So the road to profitability is definitely driven by using the capacity and driving revenue. So there’s a certain amount of fixed cost in this business that requires the top line to be at a certain level. The in the cell and gene therapy space, the distinction between a later stage clinical and a commercial from a revenue perspective isn’t actually that large for most part. So we are we can build a clinical pipeline and become profitable for sure.

We don’t need a commercial client. Certainly, commercial a commercial client gives you stability and does not have the peaks and valleys. So it’s a nice thing to have. But our clinical pipeline is strong at this stage, and we believe we can build that with new clients coming in.

Dave Windley, Analyst, Jefferies Healthcare Equity Research: Got it. On the I believe you have two commercial client you have one kind of normalized commercial client and then one where the volumes were declining or dropping. Is is the one where the volumes are diminished in 2025, should we view that as temporary? Or is 2025 reflective of run rate with that client?

Burgett Gershuk, EVP and Chief Operating Officer, Charles River Laboratories: Yes. I don’t want to go into too much detail about our clients. But what I can tell you is that with any commercial program there is a ramp up period where the negotiations was how reimbursements will work, finding the right clients, approvals in different countries. So with any commercial program, we expect a ramp over a few years and we would expect that here too. And maybe just to say in this business, the CDMO business specifically, we have done a ton of improvements over the last years.

There’s which is a lot of investment. So we have improved regulatory compliance both from processes as well as in the facilities. We made a lot of investments in our facilities. We brought in new leadership. We had for the longest time consulting groups helping us was getting the a clinical stage company into a commercial stage.

All of those things over time will become a new normal or will reduce and will help us to become more profitable.

Dave Windley, Analyst, Jefferies Healthcare Equity Research: Got it. Okay. So let’s move to DSA. In that largest segment, you mentioned stronger bookings back to circa one point zero book to bill and strength on the large pharma side. Maybe we could delve into that a little bit in terms of what clients did clients provide any color on why that why the kind of demand perked back up again?

And are you seeing that as a sustainable level?

Burgett Gershuk, EVP and Chief Operating Officer, Charles River Laboratories: Yes. So thanks, Dave. That’s a really good question. So it’s I’ll start with pharma and then I’ll talk a little bit about biotech too. So from our pharma clients, what we have seen is a solid growth in bookings in Q1.

And we attribute this a little bit to timing because it was right after the budgets have been approved early in the year. Clients know what programs they’re going to move forward with. And so we are cautiously optimistic obviously about the future and the rest of the year. But we do think that some of this booking early bookings was just was a timing perspective. The revenue for Pharma is still on a declining rate for Q1 and Q2.

And we believe that’s primarily because the anniversary of our Pharma decline started really in H2 of last year. So we haven’t anniversaried it yet. Looking at BioTek, there is the trend is a little bit opposite or different. We have seen now two quarters of growth in our biotech segment, which is really nice to see obviously. Booking trends metrics are stable to slightly improving, But we are very pragmatic in our outlook for biotech and very cautious for our outlook for biotech because after a good year of funding or a decent year of funding in 2024, So far this year is hasn’t been that great.

So and we need to see that the clients that we’re serving have to funds maintain the work and that this this this mental situation isn’t changing, that people don’t don’t get overly cautious again because they’re seeing that either in the news, trying to conserve cash and and or not. But at this point, what we have seen has been very positive. You specifically asked about client conversations. Obviously, we always have them. Our pharma clients at the people that we are talking to, which is in the heads of preclinical and in that stage are optimistic about the year.

They are optimistic about their programs moving forward, being back to work, having prioritized work, knowing where they’re going. But again, we are kind of last year, there was a lot of discussion obviously in boardrooms and CEO level and was a lot of the rhetoric that’s coming out of the new administration and tariffs and truck pricing and niche state, we just need to see where this is going. The same was biotech. We we get positive vibes, but want to make sure that we are not over forecasting.

Dave Windley, Analyst, Jefferies Healthcare Equity Research: Sure. On the just to clarify on the biotech, you mentioned two quarters of growth. Was that revenue bookings or both? Revenue. Okay.

And in large pharma, we’ve seen I won’t say a megatrend, but something of a trend of pharma licensing. We’ve seen a few deals announced, pharma licensing of some Chinese compound, Chinese assets. How if at all do you think about that affecting the large pharma demand for preclinical activity?

Burgett Gershuk, EVP and Chief Operating Officer, Charles River Laboratories: So when pharma is licensing in a program for some of those programs that were press released, we’re doing some work on it. We’re obviously not doing the very early stage work because that was done then in China. But there’s often some follow on work or some validating work, meaning we do some studies because maybe the dataset wasn’t quite to the expectation of the pharma companies. So there is some follow on work, but I certainly would, from a preclinical perspective, would rather see that work originating out of The U. S.

Biotech company.

Dave Windley, Analyst, Jefferies Healthcare Equity Research: Okay. I thought that might be the case, but I wanted to clarify. And then, you mentioned the biotech funding environment. Can you talk about, at a high level, when I think about business mix for total company, the kind of academic government piece is more substantial for Charles River than, say, for some of the later stage clinical players. But I think that academic government piece contribution is really in RMS, in a different segment.

So if we were to focus on DSA, I’m going say Todd’s probably going to tell you not to give me numbers. But can you give kind of ballparks of how does that split look between pharma and biotech and DSA?

Burgett Gershuk, EVP and Chief Operating Officer, Charles River Laboratories: Yes. So if you look at pharma and biotech, what I can tell you, it’s very similar to total company. So we do more biotech work than pharma. And so that’s it’s kind of very similar. Okay.

Okay.

Dave Windley, Analyst, Jefferies Healthcare Equity Research: And then how are you thinking about price versus volume in your study activity? Like price is many faceted in small animal, large animal has had an interesting inflation kind of few years and deflation year probably. But how are price and volume intermixing into that segment?

Burgett Gershuk, EVP and Chief Operating Officer, Charles River Laboratories: Are you looking at DSA

Dave Windley, Analyst, Jefferies Healthcare Equity Research: or DSA.

Burgett Gershuk, EVP and Chief Operating Officer, Charles River Laboratories: DSA. DSA. Okay. So for the first quarter, we actually saw a positive pricemix trend that was great to see, a little bit more mix than I would call it price. So we had some nice longer term chronic studies, but also some four week NHP work that in both cases, the pricing pressure is lower than on some of the other work.

And that has translated into a positive pricemix impact for our segment and our business. We don’t necessarily foresee that for the upcoming quarters. We believe that price will still be a headwind. Even so, we believe it’s stable from what we’ve seen last year. Just that it hasn’t deteriorated further, but we’re also not expecting a major improvement for the next few quarters.

Dave Windley, Analyst, Jefferies Healthcare Equity Research: Okay. And just for clarity, because I’ll probably get this question. What you just described is it consistent with your thinking at the end of the last quarter, I. E, is what you just described in the guidance?

Burgett Gershuk, EVP and Chief Operating Officer, Charles River Laboratories: Yes. So we are reaffirming the guidance, which should give you the confidence.

Dave Windley, Analyst, Jefferies Healthcare Equity Research: Got it. So let’s move on to the FDA announcement. So I think people have sobered up a little bit in terms of the rate and pace of transition from animal studies to NAMS. Some of us were recently at a meeting where some there were some examples given of, you know, NAMS that have been developed and the and the time frame to get to a validated NAMS that really can be used in what I’ll call production. So I don’t know if you have examples in mind like that, but it this is a five to ten to maybe twenty year journey to to validate these things.

How how I don’t wanna lead the witness, but how how would you describe this journey?

Burgett Gershuk, EVP and Chief Operating Officer, Charles River Laboratories: Yeah. So let me answer that question and then maybe go a little bit into where we are playing here, if possible. So historically, absolutely. So to validate a name, have it used in particular regulated space requires a lot of validation, a lot of data that’s translated and has taken and and to get it through FDA and some other of the regulatory regulatory bodies has historically taken a decade, maybe longer. Right?

But what I wanna, maybe focus on a little bit more is that, for me, the the NAMS, discussion is is an evolution from what we have done over the last two to three decades. Meaning, we used to call it three r’s, reduce, refine, replace, and that’s still what we’re talking about, and the NAMS is is a part of that. Charles River has always played a leading role in finding ways to reduce the use of animals, bringing new technologies in, bringing names in, looking at study protocols, working with the FDA reviewers, working with our clients to make sure that we are as pragmatic as possible in the use of animals. And we will continue to do that. We are actually doing $200,000,000 of revenue right now with NAMS.

And we have invested, which we formally launched last year, a program called AMAP, which is Alternative Methods Advancement Program, where we said we have invested $200,000,000 already through partnerships and M and A as well as some organic developments, and we will continue about at the same level going forward. So for us, this is the evolution of drug development. For us, this wasn’t really coming at a surprise except the announcement came at a surprise. But we are applauding, the FDA leadership in their focus on this area, which the FDA always had committees in other areas and see how we can drive that forward. So it will be interesting to see where we go with that.

Dave Windley, Analyst, Jefferies Healthcare Equity Research: Is it right to think in terms of the FDA’s selection of mAbs? First of all, I think people have kind of learned that maybe it’s obvious because there were some tests that weren’t particularly efficacious or not particularly telling, in testing of mAbs. But is it also right to think that maybe the impact there would be more on the NHP side than the small animal side?

Burgett Gershuk, EVP and Chief Operating Officer, Charles River Laboratories: Yeah. So, the FDA had, announced a pilot program on the use of, or in the space of mAbs monoclonal antibodies, specifically chronic studies. And, what, Dave, what you’re referring to is we announced that we make, we do roughly $60,000,000 in chronic studies. 50,000,000 of that is NHPs. So definitely more NHPs than small animals.

We already have several clients who used a weight of evidence, argument, basically went to the FDA, said, I don’t think I need to do a chronic study because we have not seen anything in three months. And if you don’t see anything in three months, you probably won’t see anything in a longer term study. So part of that is already in our base, and we do think that there are arguments to be made. And this is something that we definitely see will be implemented for for many of those studies going forward. MAPs are much more defined, known toxicity.

And, you know, and and generally, as as as we said, if you don’t see anything in three months, you may not see something in six months, but that needs to be worked through. So I do think this is the right target area for the FDA to focus on and do a pilot project on. And as I said, we are already working with our clients in many cases. Some do the chronic study, but not the three months. So it’s it’s it’s a real it’s a mix right now, and we will continue to work with them on that.

Dave Windley, Analyst, Jefferies Healthcare Equity Research: Got it. We’ve got about a minute left. So let’s just throw one in on RMS here before we leave. And your that is, as we said earlier, the area where you do have a little more direct exposure to government and academic spending. Update us on the budget spending environment in among those government and academic clients with the Trump administration scrutiny on those related topics?

Burgett Gershuk, EVP and Chief Operating Officer, Charles River Laboratories: Yeah. Certainly happy to. So just to to size it a little bit. So academia, North American academia and government is about 6% of Charles River, so a a relatively small part. NIH is 2% off that 6%, so even a smaller part.

But it’s a bit it’s an important segment for RMS, so it translates to about 20% of RMS. At this stage, we have not seen a material impact from, the NIH or grants or academia, but there’s a lot of discussions about, what impact it might have. If we do see, we’re working directly for the NIH or other government agencies for some of our IES contracts. If we do see an impact there, we expect to see that may earliest in 2026 because those contracts generally work their way through first and just don’t get renewed. But we don’t expect that to be a big part of our revenue because it’s just a very small segment.

From an academia perspective, we’ll have to see how that impacts animal purchases. But to remind you, an animal purchase is a very small part of their research dollars. It’s actually a very inexpensive part of drug development. And, for academia, buying animals is a direct cost versus breeding animals or having their own bevarium is a indirect cost. So you actually might could see stable or maybe even an upside because there might be a little bit of a switchover.

Something similar we have seen in a prior decade, of that. So more to be seen, but we don’t think it will have a big impact on Charles River.

Dave Windley, Analyst, Jefferies Healthcare Equity Research: Yeah. Important distinction on the direct and indirect. I appreciate that. So, Burgett, thanks for your time, and thanks to everybody in the audience for your attendance and,

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