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Vigil Neuroscience, Inc., a clinical-stage biotechnology company, focuses on developing treatments for rare and common neurodegenerative diseases by restoring the vigilance of microglia, the sentinel immune cells of the brain. Its lead candidate is VGL101(Iluzanebart), a human monoclonal antibody agonist targeting human triggering receptor expressed on myeloid cells 2 and is in a Phase 2 trial in patients with adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP), a rare and fatal neurodegenerative disease. The company is also developing VG-3927, an orally-available small molecule TREM2 agonist to treat common neurodegenerative diseases associated with microglial dysfunction, with an initial focus on Alzheimer’s disease in genetically defined subpopulations, which is being evaluated in a Phase 1 clinical trial. It has license agreement with Amgen Inc. to commercially develop, manufacture, use, distribute, and sell therapeutic products containing compounds that bind to TREM2. The company was incorporated in 2020 and is headquartered in Watertown, Massachusetts.
Name | Age | Since | Title |
---|---|---|---|
Ivana Magovcevic-Liebisch | 56 | 2020 | President, CEO & Director |
Stefan Vitorovic | 38 | 2021 | Independent Director |
Marco Colonna | - | - | Chairman of Scientific Advisory Board |
Bruce L. Booth | 49 | 2020 | Independent Chairman of the Board |
Gerhard Koenig | 62 | 2020 | Independent Director |
Mary T. Thistle | 63 | 2022 | Independent Director |
Cheryl Renee Blanchard | 59 | 2020 | Independent Director |
John Dunlop | - | - | Member of Scientific Advisory Board |
Samantha Budd Haeberlein | - | 2023 | Independent Director |
Jaime Grutzendler | - | - | Member of Scientific Advisory Board |
Bradley T. Hyman | - | - | Member of Scientific Advisory Board |
Suzanne L. Bruhn | 60 | 2022 | Independent Director |
Ole Isacson | - | 2022 | Member of Scientific Advisory Board |
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