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TYK Medicines, Inc., a clinical-stage biopharmaceutical company, research, development and commercialization of pharmaceutical products. Its lead product candidate is TY-9591, a third-generation epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor for the treatment of brain metastases from non-small cell lung cancer (NSCLC) with EGFR mutations, and in locally advanced or metastatic NSCLC with EGFR L858R mutation. The company also develops TY-302, an oral cyclin-dependent kinase (CDK) 4/6 inhibitor to treat solid tumors, including breast cancer and prostate cancer; TY-2136b, an oral ROS proto-oncogene 1/neurotrophic tyrosine receptor kinase inhibitor for the treatment of solid tumors; TY-2699a, a selective CDK7 inhibitor for the treatment of advanced/metastatic solid tumors; and TY-0540, a selective CDK2/4/6 inhibitor to treat advanced/metastatic solid tumors. In addition, it develops TY-4028, an oral exon 20 insertion-TKI targeting locally advanced or metastatic NSCLC with EGFR exon 20 or HER2 exon 20 insertions; TY-1091, a potent and selective rearranged during transfection proto-oncogene (RET) inhibitor for the treatment of advanced NSCLC with RET gene fusion, advanced medullary thyroid cancer with RET gene mutation, and other advanced solid tumors with RET gene alterations; TY-1054, an oral yes associated protein-transcriptional enhanced associate domain inhibitor for cancer treatment; TY-1210, a selective CDK2 inhibitor to treat solid tumors; TY-0609, a selective CDK4 inhibitor for the treatment of cancer; and TY-3200, an EGFR degrader. The company was incorporated in 2017 and is headquartered in Huzhou, China.
Name | Age | Since | Title |
---|---|---|---|
Eric Hong Gu | 58 | 2017 | Non-Executive Director |
Wenqing Xu | 59 | 2024 | Independent Non- Executive Director |
Xiaoying Meng | 44 | 2021 | Non-Executive Director |
Jun Li | 61 | 2021 | Co-Founder & Non-Executive Director |
Yusheng Wu | 60 | 2017 | Founder, Executive Chairman & CEO |
Xiuhua Shen | 52 | 2024 | Independent Non- Executive Director |
Chengshan Niu | 43 | 2018 | Chairperson of the Supervisory Board & Senior Dir. of Medicinal Chemistry Dept. |
Yuting Leng | 41 | 2024 | Independent Non- Executive Director |
Senquan Zhang | 48 | 2024 | Independent Non- Executive Director |
Mingyu Jiang | 37 | 2019 | Non-Executive Director |
Jing Shang | 43 | 2021 | Shareholder Representative Supervisor |
Xiangyang Zhu | - | 2025 | Non-Executive Director |
Apeng Liang | 43 | 2017 | Employee Representative Supervisor & Director of the Medicinal Chemistry Department |
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