Karyopharm Therapeutics Inc., a commercial-stage pharmaceutical company, discovers, develops, and commercializes drugs directed against nuclear export for the treatment of cancer and other diseases in the United States. The company discovers, develops, and commercializes novel and small molecule Selective Inhibitor of Nuclear Export (SINE) compounds that inhibit the nuclear export protein exportin 1 (XPO1). Its lead compound, include XPOVIO in combination with bortezomib and dexamethasone for the treatment of adult patients with multiple myeloma; in combination with dexamethasone for the treatment of adult patients with relapsed or refractory multiple myeloma; and for the treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL). It also developing Selinexor for treating hematological and solid tumor malignancies, including multiple myeloma, endometrial cancer, myelofibrosis, and DLBCL; and ELTANEXOR for treating Myelodysplastic Neoplasms, as well as verdinexor, KPT-9274, and IL-12 compounds. In addition, the company has license agreement with Menarini Group to develop and commercialize selinexor for human oncology indications; license agreement with Antengene Therapeutics Limited to develop and commercialize selinexor, eltanexor, and KPT-9274 for the treatment and/or prevention of human oncology indications, as well as verdinexor for the diagnosis, treatment, and/or prevention of human non-oncology indications; and distribution agreement for the commercialization of XPOVIO with FORUS Therapeutics Inc. Further, the company has a collaboration with Bristol Myers Squibb company to evaluate novel cereblon E3 ligase modulator agent mezigdomide in combination with Selinexor in patients with relapsed/refractory multiple myeloma. Karyopharm Therapeutics Inc. was incorporated in 2008 and is headquartered in Newton, Massachusetts.
Pipeline Promise | Karyopharm's clinical trials in myelofibrosis and endometrial cancer could potentially double annual revenue, with data expected by early 2026 |
Financial Tightrope | Despite steady Xpovio sales, cash burn and delayed study timelines raise concerns about future funding needs and potential market challenges |
Valuation Disconnect | Analysts see significant upside potential, with price targets ranging from $3 to $33, suggesting the stock may be undervalued given its pipeline prospects |
Competitive Edge | Explore how Karyopharm's unique SINE compound technology positions it in the oncology market, with potential for expansion into multiple cancer indications |
Metrics to compare | KPTI | Sector Sector - Average of metrics from a broad group of related Healthcare sector companies | Relationship RelationshipKPTIPeersSector | |
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P/E Ratio | −0.4x | −0.5x | −0.6x | |
PEG Ratio | −0.03 | −0.02 | 0.00 | |
Price/Book | −0.2x | 2.4x | 2.6x | |
Price / LTM Sales | 0.4x | 6.9x | 3.3x | |
Upside (Analyst Target) | 221.5% | 314.4% | 40.1% | |
Fair Value Upside | Unlock | 15.9% | 5.3% | Unlock |