Nuvalent, Inc., a clinical-stage biopharmaceutical company, engages in the development of therapies for patients with cancer. Its lead product candidates are NVL-520, a novel ROS1-selective inhibitor to address the clinical challenges of emergent treatment resistance, central nervous system (CNS)-related adverse events, and brain metastases that may limit the use of ROS1 tyrosine kinase inhibitors (TKIs) for patients with ROS proto-oncogene 1 (ROS1)-positive non-small cell lung cancer (NSCLC) which is under the Phase 2 portion of the ARROS-1 Phase 1/2 clinical trial; NVL-655, a brain-penetrant ALK-selective inhibitor, to address the clinical challenges of emergent treatment resistance, CNS-related adverse events, and brain metastases that might limit the use of first-, second-, and third-generation ALK inhibitors that is under the Phase 2 portion of the ALKOVE-1 clinical trial; and NVL-330, a brain-penetrant human epidermal growth factor receptor 2 (HER2)-selective inhibitor designed to treat tumors driven by HER2ex20, brain metastases, and avoiding treatment-limiting adverse events including due to off-target inhibition of wild-type EGFR that is in Phase 1a/1b clinical trial. The company was incorporated in 2017 and is headquartered in Cambridge, Massachusetts.
Pivotal Pipeline | Explore Nuvalent's innovative TKIs for NSCLC, with zidesamtinib and neladalkib leading the charge against ROS1 and ALK mutations |
2025: Year of Truth | Anticipate crucial data readouts and potential NDA submission, setting the stage for Nuvalent's market entry and valuation shifts |
Market Potential | Analysts project revenue growth from $205M in 2026 to $4.5B by 2032, reflecting optimism in Nuvalent's long-term prospects |
Analyst Outlook | Average price target of $101.43, with estimates ranging from $100 to $110, underscoring confidence in Nuvalent's strategic direction |
Metrics to compare | NUVL | Sector Sector - Average of metrics from a broad group of related Healthcare sector companies | Relationship RelationshipNUVLPeersSector | |
---|---|---|---|---|
P/E Ratio | −15.8x | −3.1x | −0.6x | |
PEG Ratio | 0.21 | 0.02 | 0.00 | |
Price/Book | 5.8x | 1.3x | 2.6x | |
Price / LTM Sales | - | 152.7x | 3.3x | |
Upside (Analyst Target) | 49.3% | 202.7% | 39.1% | |
Fair Value Upside | Unlock | 4.5% | 4.5% | Unlock |