Nuvalent, Inc., a clinical-stage biopharmaceutical company, engages in the development of therapies for patients with cancer. Its lead product candidates are NVL-520, a novel ROS1-selective inhibitor to address the clinical challenges of emergent treatment resistance, central nervous system (CNS)-related adverse events, and brain metastases that may limit the use of ROS1 tyrosine kinase inhibitors (TKIs) for patients with ROS proto-oncogene 1 (ROS1)-positive non-small cell lung cancer (NSCLC) which is under the Phase 2 portion of the ARROS-1 Phase 1/2 clinical trial; NVL-655, a brain-penetrant ALK-selective inhibitor, to address the clinical challenges of emergent treatment resistance, CNS-related adverse events, and brain metastases that might limit the use of first-, second-, and third-generation ALK inhibitors that is under the Phase 2 portion of the ALKOVE-1 clinical trial; and NVL-330, a brain-penetrant human epidermal growth factor receptor 2 (HER2)-selective inhibitor designed to treat tumors driven by HER2ex20, brain metastases, and avoiding treatment-limiting adverse events including due to off-target inhibition of wild-type EGFR that is in Phase 1a/1b clinical trial. The company was incorporated in 2017 and is headquartered in Cambridge, Massachusetts.
Pioneering NSCLC Care | Nuvalent's brain-penetrant TKIs target ROS1 and ALK-positive NSCLC, with pivotal data expected in 2025, potentially reshaping treatment paradigms |
Financial Landscape | Despite current losses, analysts project revenues of $205M by 2026, with ambitious growth estimates reaching $4.5B by 2032, contingent on approvals |
Competitive Edge | Explore how Nuvalent's focus on brain-penetrant TKIs uniquely positions it in the crowded NSCLC market, addressing critical unmet needs in treatment |
Future Horizons | Delve into Nuvalent's expansion potential beyond NSCLC, with HER2-selective TKI NVL-330 opening doors to broader oncology applications |
Metrics to compare | NUVL | Sector Sector - Average of metrics from a broad group of related Healthcare sector companies | Relationship RelationshipNUVLPeersSector | |
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P/E Ratio | −18.9x | −4.5x | −0.5x | |
PEG Ratio | 0.23 | 0.02 | 0.00 | |
Price/Book | 5.6x | 3.1x | 2.6x | |
Price / LTM Sales | - | 192.5x | 3.2x | |
Upside (Analyst Target) | 41.9% | 167.9% | 42.0% | |
Fair Value Upside | Unlock | 8.1% | 6.6% | Unlock |