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ORIC Pharmaceuticals, Inc., a clinical-stage biopharmaceutical company, engages in the discovery and development of therapies to counter the resistance mechanisms cancers in the United States. Its clinical stage product candidates include ORIC-114, a brain penetrant orally bioavailable irreversible inhibitor, currently under Phase 1b study, that selectively target epidermal growth factor receptor (EGFR) exon 20 and human epidermal growth factor receptor 2 exon 20 with high potency towards exon 20 insertion mutations; and ORIC-944, an allosteric inhibitor of the polycomb repressive complex 2 for prostate cancer, currently under Phase 1b study. The company develops ORIC-533, an orally bioavailable small molecule inhibitor of CD73; and ORIC-613, a small molecule therapeutic intended to address a mechanism of innate resistance found in a subset of breast cancers. It has clinical development collaboration agreement for a potential Phase 2 study of ORIC-533 in multiple myeloma with Pfizer Inc.; a clinical trial collaboration and supply agreement with Bayer to evaluate ORIC-944 in combination with Nubeqa AR inhibitor; and a clinical trial collaboration and supply agreement with Johnson & Johnson to evaluate ORIC 944 in combination with Erleada AR inhibitor. The company was incorporated in 2014 and is headquartered in South San Francisco, California.
Name | Age | Since | Title |
---|---|---|---|
Peter H. E. Svennilson | 59 | 2014 | Independent Director |
Laurence A. Lasky | 70 | 2015 | Member of Scientific Advisory Board |
Mardi C. Dier | 57 | 2020 | Independent Director |
Lori Anne Kunkel | 63 | 2020 | Independent Director |
Charles L. Sawyers | 63 | - | Co-Founder & Member of Scientific Advisory Board |
Jacob M. Chacko | 43 | 2018 | President, CEO & Director |
Scott W. Lowe | - | - | Co-Founder & Member of Scientific Advisory Board |
Richard A. Heyman | 66 | 2015 | Co-Founder, Independent Chairman & Member of Scientific Advisory Board |
Angie J. You | 49 | 2021 | Independent Director |
Steven L. Hoerter | 53 | 2021 | Independent Director |
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