Arvinas, Inc., a clinical-stage biotechnology company, engages in the discovery, development, and commercialization of therapies to degrade disease-causing proteins. The company engineers proteolysis targeting chimeras (PROTAC) targeted protein degraders that are designed to harness the body’s own natural protein disposal system to degrade and remove disease-causing proteins. Its product pipeline includes Bavdegalutamide and ARV-766, investigational orally bioavailable PROTAC protein degraders for the treatment of men with metastatic castration-resistant prostate cancer, which are in Phase 3 clinical trials; and ARV-471, an orally bioavailable estrogen receptor degrading PROTAC targeted protein degrader for the treatment of patients with locally advanced or metastatic estrogen receptor+/human epidermal growth factor receptor 2-breast cancer, which is Phase 3 clinical trial. The company’s products also consists ARV 393, orally bioavailable PROTAC designed to degrade BCL6, a transcriptional repressor and a key regulator of normal B-cell maturation and differentiation processes which is in Phase 1 first-in-human clinical trial; ARV 102 for the treatment of neurodegenerative diseases, which is in Phase 1 clinical trial; and KRAS G12D program is in preclinical development for pancreatic and colorectal cancers. Arvinas, Inc. has collaborations with Pfizer Inc., Genentech, Inc., F. Hoffman-La Roche Ltd., Carrick Therapeutics Limited, and Bayer AG. The company was founded in 2013 and is based in New Haven, Connecticut.
Vepdegestrant's Promise | Explore vepdegestrant's potential as a first-in-class oral PROTAC for ESR1-mutant breast cancer patients, with promising efficacy in recent trials |
Financial Crossroads | Delve into Arvinas's strategic restructuring and financial outlook, balancing cost-cutting measures with a healthy cash position and extended runway |
Market Dynamics | Learn about the challenges Arvinas faces in the competitive oral SERD market, with analyst price targets ranging from $10 to $48 |
Platform Potential | Discover the broader implications of Arvinas's PROTAC platform technology, offering opportunities beyond vepdegestrant in addressing "undruggable" proteins |
Metrics to compare | ARVN | Sector Sector - Average of metrics from a broad group of related Healthcare sector companies | Relationship RelationshipARVNPeersSector | |
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P/E Ratio | −7.8x | −2.9x | −0.6x | |
PEG Ratio | −0.10 | 0.21 | 0.00 | |
Price/Book | 0.9x | 2.8x | 2.6x | |
Price / LTM Sales | 1.5x | 1.8x | 3.3x | |
Upside (Analyst Target) | 86.9% | 113.6% | 39.1% | |
Fair Value Upside | Unlock | 12.9% | 5.4% | Unlock |