Arvinas, Inc., a clinical-stage biotechnology company, engages in the discovery, development, and commercialization of therapies to degrade disease-causing proteins. The company develops proteolysis targeting chimeras (PROTAC) targeted protein degraders that are designed to harness the body’s own natural protein disposal system to degrade and remove disease-causing proteins. It is also developing clinical development programs , including ARV-102, a leucine-rich repeat kinase 2 (LRRK2) protein for the treatment of neurodegenerative diseases, such as Parkinson's disease and progressive supranuclear palsy; ARV-806, a Kirsten rat sarcoma, G12D protein for the treatment of cancers with the G12D mutation, comprising pancreatic, colorectal, and non-small cell lung cancer; ARV-393, a B-cell lymphoma 6 protein for the treatment of relapsed/refractory non-Hodgkin lymphoma (NHL); ARV-027, a polyglutamine-expanded androgen receptor in skeletal muscle; and vepdegestrant, an estrogen receptor for the treatment of locally advanced or metastatic ER+/HER2- breast cancer. In addition, the company develops Bavdegalutamide (ARV-110) and Luxdegalutamide (ARV-766), investigational orally bioavailable PROTAC protein degraders for the treatment of men with metastatic castration-resistant prostate cancer. It has collaborations with Pfizer Inc., Genentech, Inc., F. Hoffman-La Roche Ltd., Carrick Therapeutics Limited, and Bayer AG. The company was founded in 2013 and is based in New Haven, Connecticut.
Vepdegestrant's Promise | Explore vepdegestrant's potential as a first-in-class oral PROTAC for ESR1-mutant breast cancer patients, with promising efficacy in recent trials |
Financial Crossroads | Delve into Arvinas's strategic restructuring and financial outlook, balancing cost-cutting measures with a healthy cash position and extended runway |
Market Dynamics | Learn about the challenges Arvinas faces in the competitive oral SERD market, with analyst price targets ranging from $10 to $48 |
Platform Potential | Discover the broader implications of Arvinas's PROTAC platform technology, offering opportunities beyond vepdegestrant in addressing "undruggable" proteins |
Metrics to compare | ARVN | Sector Sector - Average of metrics from a broad group of related Healthcare sector companies | Relationship RelationshipARVNPeersSector | |
|---|---|---|---|---|
P/E Ratio | −8.3x | −9.1x | −0.4x | |
PEG Ratio | −0.14 | 0.15 | 0.00 | |
Price/Book | 1.5x | 3.6x | 2.6x | |
Price / LTM Sales | 2.5x | 17.9x | 3.2x | |
Upside (Analyst Target) | 48.5% | 40.3% | 46.2% | |
Fair Value Upside | Unlock | −3.1% | 7.2% | Unlock |