Precision BioSciences, Inc., a clinical stage gene editing company, develops in vivo gene editing therapies for gene edits, including gene insertion, excision, and elimination in the United States. The company offers ARCUS, a genome editing platform for DNA genome insertion, removal, and repair. It also provides PBGENE-HBV for the treatment of chronic hepatitis B virus (HBV) to eliminate covalently closed circular DNA with direct cuts and edits, as well as to inactivate integrated HBV DNA with the goal of long-lasting reductions in hepatitis B surface antigen; and PBGENE-3243 for the treatment of m.3243 associated mitochondrial myopathy. In addition, the company develops PBGENE-NVS (insertion) for sickle cell and beta thalassemia diseases; PBGENE-DMD (excision) for duchenne muscular dystrophy; PBGENE-LIVER (insertion), a liver directed target; PBGENE-CNS (excision), a central nervous system directed target; and iECURE-OTC (insertion) for ornithine transcarbamylase deficiency. It has collaboration agreements with Novartis Pharma AG to discover and develop in vivo gene editing products; TG Cell Therapy, Inc. to develop, manufacture, and commercialize azer-cel for autoimmune diseases and other indications outside of cancer; and iECURE, Inc. to develop ARCUS-based gene-insertion therapies. Precision BioSciences, Inc. was incorporated in 2006 and is headquartered in Durham, North Carolina.
ARCUS Advancement | Precision BioSciences' ARCUS gene editing platform approaches clinical milestone with PBGENE-HBV program, showcasing potential in treating genetic disorders |
Financial Runway | $140 million cash position extends operations into 2026, supporting pipeline development amid pre-revenue status and ongoing R&D investments |
Partnerships in Focus | Strategic collaborations with Novartis and Eli Lilly validate ARCUS platform, while recent changes reshape pipeline and control over key assets |
Market Outlook | Analysts maintain cautious stance with $34 price target, suggesting 205.8% upside potential contingent on successful clinical outcomes and commercialization |
Metrics to compare | DTIL | Sector Sector - Average of metrics from a broad group of related Healthcare sector companies | Relationship RelationshipDTILPeersSector | |
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P/E Ratio | −2.4x | −5.1x | −0.5x | |
PEG Ratio | −0.04 | −0.16 | 0.00 | |
Price/Book | 1.1x | 2.1x | 2.6x | |
Price / LTM Sales | 1.0x | 10.1x | 3.3x | |
Upside (Analyst Target) | - | 110.4% | 43.5% | |
Fair Value Upside | Unlock | 11.0% | 6.3% | Unlock |