Spruce Biosciences, Inc. is a biopharmaceutical company focused on developing and commercializing novel therapies for neurological disorders. The company develops TA-ERT, a fusion protein comprised of recombinant human alpha-N-acetylglucosaminidase, which is an enzyme replacement therapy for patients with Sanfilippo Syndrome Type B. It also develops Tildacerfont for treating a highly debilitating mental disorder characterized by depressed mood with cognitive-affective and somatic changes, including anhedonia, weight alterations, and altered sleeping patterns. In addition, the company develops SPR202 for the treatment of Congenital Adrenal Hyperplasia (CAH), a chronic and potentially life-threatening rare disease with no cure, and SPR204, a monoclonal antibody antagonist for Post-Bariatric Hypoglycemia. The company has a license agreement with Eli Lilly and Company to research, develop, and commercialize various pharmaceutical compounds. It also has a collaboration and license agreement with Kaken Pharmaceutical Co. Ltd. to develop, manufacture, and commercialize Tildacerfont for the treatment of CAH in Japan. Spruce Biosciences, Inc. was incorporated in 2014 and is headquartered in South San Francisco, California.
Tildacerfont Trials | Spruce Biosciences' future hinges on pivotal CAHmelia-204 and CAHptain-205 trials for tildacerfont, with results expected in Q4 2024 |
Market Dynamics | Explore the competitive landscape of CAH treatment, with Spruce facing challenges from Neurocrine Biosciences' crinecerfont in a market of 20,000-30,000 US patients |
Financial Health | With $70M cash runway through 2025, Spruce Biosciences navigates critical development phases while exploring strategic alternatives to maximize shareholder value |
Analyst Outlook | Price targets range from $1.50 to $3.00, reflecting varied perspectives on Spruce's potential in CAH treatment and expansion into Major Depressive Disorde |
Metrics to compare | SPRB | Sector Sector - Average of metrics from a broad group of related Healthcare sector companies | Relationship RelationshipSPRBPeersSector | |
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P/E Ratio | −0.1x | −4.1x | −0.5x | |
PEG Ratio | 0.01 | −0.20 | 0.00 | |
Price/Book | 0.3x | 1.9x | 2.6x | |
Price / LTM Sales | 1.7x | 9.4x | 3.2x | |
Upside (Analyst Target) | - | 70.9% | 41.2% | |
Fair Value Upside | Unlock | 25.1% | 6.2% | Unlock |